The Study On Coronary Heart Disease Patients With Impaired Glucose Tolerance Of The Level Of Serum Inflammatory Factors And Coronary Angiography Results

Objective：This study investigated the relationship between coronary angiographyresults mainly from the metabolism of glucose and serum levels ofinflammatory factors in patients with coronary heart disease and thedevelopment of coronary heart disease, coronary heart disease patients withglucose tolerance in addition to the positive treatment coronary anomaly, stillneed to consider strengthening of postprandial hyperglycemia screening, theimportance of early intervention to reduce the incidence of IGT stage,new-onset diabetes and cardiovascular disease has important significance.Method：152Patients in our hospital received coronary angiography in2011September to2012March(initially be diagnosed as coronary heart disease,and without systematic medication before hospitalization).Random extract30patients with CHD(A group),17males,13females,The average age is57.3years old;30CHD patients with IGT (B group),19males,11females,Theaverage age is56.1years old;30CHD patients with diabetes mellitus (Cgroup),16males,14females,The average age is55.7years old.Collectedblood samples,Compare serum levels of four kinds of inflammatory factors(MMP-2, MMP-9, CRP, ox-LDL),Using quantitative Gensini integral systemevaluate the severity of coronary artery disease (the degree of stenosis and thenumber of patches), correlation between inflammatory factor and coronaryangiography results.30cases of B patients were randomly divided into D group and E group,10patients with taking acarbose (D group),2males,8females,,The average age is55.9years old;10patients without takinghypoglycemic drugs (E group),7males,3females,,The average age is56.2years old.D group and E group were applied conventional treatment,compare two groups of1months,3months of four kinds of inflammatoryfactor(MMP-2, MMP-9, CRP, ox-LDL).Result：1, The age, gender, hypertension, smoking, drinking, TC, TG, LDL-C ofpatients, no significant difference was found between the groups, p>0.05.fasting blood glucose of CHD with diabetes mellitus group is higherthan CHD.2, CHD with IGT group (the degree of stenosis and the number ofpatches) is similar to CHD with diabetes mellitus group, Those weremore aggravated than CHD group; three groups of the number of coronaryartery lesions:P（BC）=0.59571, P（AB）=0.05171, P（AC）=0.04255; Threegroups of the severity of coronary artery lesions:P （AC）=0.71197， P（AB）=0.00574，P（AC）=0.00574.Statistical results suggest that the cardiovascularcomplications of IGT is similar to DM.3, percentage of3groups’ PCI treatment: CHD group is70.0%, CHDwith IGT group is77.3%, CHD with diabetes mellitus group is88.7%;3groupshave no obvious difference on PCI treatment, P=0.275; because the coronarydamage is heavy in the CHD with IGT group and CHD with diabetes mellitusgroup, some patients is not suitable to PCI treatment, and choose surgicaltreatment of CABG,,Once again prove CHD with IGT group of cardiovascularcomplications is similar to CHD with diabetes mellitus group.4,Comparison of three groups of MMP-2, MMP-9, CRP, ox-LDLsuggest:The serum concentration of MMP-2, MMP-9, CRP, ox-LDL in CHD with diabetes mellitus group is higher than those in CHD with IGT group;The serumconcentration of MMP-2, MMP-9, CRP, ox-LDL in CHD with IGT group ishigher than those in CHD group, P<0.05;Prove inflammatory reaction isinvolved in diabetes, impaired glucose tolerance and the formation ofatherosclerosis.5,The concentrations of MMP-2, MMP-9, CRP, ox-LDL taking acarbosepatients in CHD with IGT group is similar to no taking acarbose group In thefirst month,P>0.05;significantly decreased In the third month, P<0.05. Theconcentration of MMP-2, MMP-9, CRP in CHD with IGT group with takingacarbose,Between the zeroth month and the first month,Between the firstmonth and the third month,there is no significant difference,P>0.05; there issignificant difference between the zeroth month and the third month,P<0.05;The concentration of OX-LDL,there is no significant differencebetween the zeroth month and the first month,P>0.05;there is significantdifference between the first month and the third month, between the zerothmonth and the third month, P<0.05.The concentrations of MMP-2, MMP-9,CRP, ox-LDL not taking acarbose patients in CHD with IGT group,there is nosignificant difference between the zeroth month and the first month,betweenthe first month and the third month,between the zeroth month and the thirdmonth,P>0.05.acarbose not only reduce the level ofblood glucose, but alsoreduce the level of inflammatory factors;Acarbose inhibits inflammatoryreaction, may also has anti-atherosclerosis effect.Conclusions：1,IGT was independent risk factor of coronary heart disease, through thelevel of inflammatory factors, can confirm the long-term complications ofcardiovascular is similar to DM.2,Prove inflammatory reaction is involved in impaired glucose tolerance and the formation of atherosclerosis,and acarbose can inhibit the progress.