Analysis Of The Characteristics Of Coronary Pathological Changes And Its Related Factors In Subjects With Impaired Glucose Tolerance

Objective To investigate the characteristics of coronary's pathological changes in subjects with impaired glucose tolerance. Methods 490 cases who were suspected with ischemic chest pain were divided into three groups according to their OGTT results:(1) IGT group: n = 161, (2) T2DM group: n = 159, (3) NGT group: n = 170. Serum levels of triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL), low-density lipoprotein cholesterol (LDL) and high sensitive C-reactive protein (hs-CRP) were detected, their body mass indexes(BMI) were measured, general clinical information (including gender, age, smoking history, history of hypertension) were collected. All the CAG results were analyzed and Gensini scores were got as well. Results (1) The TG levels in T2DM group and IGT group [(2.41±1.70) mmol/l and (2.26±1.20) mmol/l] were significantly higher than that of NGT group (1.95±1.14) mmol/l, the differences were significant (P<0.01 or P<0.05), but there was no significance between IGT group and T2DM group (P>0.05); No significance was found among the three groups about their TC, HDL, LDL levels (either P>0.05). (2)The levels of hs-CRP in T2DM group [(2.38±1.76) mg/l] and IGT group [(2.33±2.03) mg/l] were increased compared with NGT group [(1.54±1.32) mg/l], the differences were significant (either P<0.01), there was no significance between IGT group and T2DM group (P>0.05). (3)The BMIs of IGT group[(25.50±3.04) kg/m2] and T2DM group [(26.09±2.86) kg/m2] were higher than that of NGT group [(24.70±3.27)kg/m2], the differences were significant (P<0.05 or P<0.01), but no significance was found between T2DM group and IGT group (P>0.05).(4) The incidence of single coronary was 44.7% in NGT group, it was higher than that of IGT group (23.6%) and T2DM group (18.9%) (either P<0.0125), but there was no significance between IGT group and T2DM group (P>0.0125); The incidences of 2 branches in T2DM group (37.1%) and IGT group (39.8%) were rose compared with NGT group (23.5%),the differences were significant (either P<0.0125), but there was no significance between IGT group and T2DM group(P>0.0125); The incidences of 3 vessels in T2DM group (40.9%) and IGT group (33.5%) were increased than that of NGT group (21.8%),the differences were significant (either P<0.0125), there was no significance between IGT group and T2DM group(P>0.0125). (5)The incidence of subtotal or total occlusion of T2DM group and IGT group were 22.6% and 18.0% respectively, both were higher than that of NGT group(7.6%)( either P<0.0125), but no difference was found between T2DM group and IGT group (P>0.0125); The incidences of extended pathological change in IGT group (24.8%) and T2DM group (30.8%) were moved upward compared with NGT group (12.4%) (either P<0.0125), but there was no significance between IGT group and T2DM group (P>0.0125).(6) The Gensini scores in IGT group (55.05±22.99)and T2DM group(56.15±24.87) were higher markedly than that of NGT group(38.03±17.38),the differences were significant (either P<0.0125), but there was no significance between IGT group and T2DM group (P>0.0125). Conclusion The incidences of 2 and 3 vessels are increased sharply in subjects with IGT, moreover, the incidences of medium, severe and extended stenosis are all increased dramatically. These manifestations are similar to patients with diabetes, we should pay much attention to those with IGT in our clinical work.