Clinical Research On Therapy Of Bradyaithythmia With The Method Of "Heart-spleen Regulation"

ObjectTo analyze how the method of “Heart-Spleen Regulation” is applied in the therapy ofbradyarrhythmiaMethod1Theory DiscussionFirstly the authorative illustrations,effective therapeutic measures and researchingtrends for bradyarrhythmia is compiled and documented, then we describe the mechanismof bradyarrhythmia with the method of “Heart-Spleen Regulation” by citing TCM classicmasterpieces and we also analyze the relevent clinical experience practiced by reputableTCM masters.2Clinical ObservationWe use SPSS17.0statistics to establish numeralized database.7relevent items arerecorded and explored by facor analysis,of which principal factors are extracted via thefactor model.We also use the cluster method to find the correlation among7itemsrecorded,and multiple linear regression to illustrate the relevence among the factors. Andthe cluster method is used again to analyze the herb formulations collected fromprescriptions of patients.Result1The two-step cluster indicates the patients suffered from bradyarrhythmia can beconsidered as one group to diagnose Zangfu syndromes with the difference of genderignored.2Diastolic pressure、systolic pressure、BMI and age are main factors.Meanwhile, matrix model produces f1(perfusion factor)、 f2(body constitution facor)and f3(diagnostic factor). 3A multiple linear regression formula is made to illustrate the correlation betweenBMI、 diastolic pressure、 age and HR,the formula appeared as Y=41.001+0.22x1-0.071x2+0.022x3,the relevence is obvious.4High-frequency herbs occurred in prescriptons is mainly composed of Qi-tonifiedherbs、Blood-tonified herbs and Qi-regulated herbs, with the flavor belongs to sweet andproperty warm and mild,and the channel runs in heart、spleen and stomach system. Viathe systematic cluster,the herbs is re-classified as5groups, also newcombinations,adhering the method of “Heart-Spleen Regulation”.Conclusion1The method of “Heart-Spleen Regulation” is fit for specialized syndrome：heart—spleen imbalance with Qi and Blood weakness. We can use the Qi-tonified herbs、Blood-tonified herbs and Qi-regulated herbs to nutrify ZhongQi,which is the principle in clinicalpractice.2Blood pressure(diastolic pressure、systolic pressure)、BMI and age are maindiagnosis and prognosis factors. A multiple linear regression formula is successfully madeto illustrate the correlation between BMI、 diastolic pressure、 age and HR,whichindicates in clinical practice we should focus on age difference、 improve cardiacperfusion by regulating diastolic pressure and change the body homeostasis by controllingthe BMI.A further investigation can be carried out if possible.3In terms of therapy of bradyarrhythmia with TCM method,we should focus onsyndromes,guided by which the prescriptions is feasible. The rules in herb combination、the property and corresponding channel of specialized herbs should be paid on emphasisin therapy and prescription, resulting in the right formula and its type.