Retrospective Analysis Of Peripheral Neuropathy In Children With Cerebral Palsy

ObjectiveTo study the characteristics of peripheral neuropathy in children with cerebral palsy and explore its possible pathogenesis.MethodCollect the data of70cerebral palsy children who were diagnosed for the first time in the Department of Neurological Rehabilitation in Children’s Hospital of Chongqing Medical University from February2010to December2011,including the symptoms and signs of nervous system, Peripheral nerve electrophysiology results and brain magnetic resonance imaging.Results1.45of70children(60.0%) had abnormal Peripheral nerve conduction function results,yet only9children(12.9%) showed weaken of tendinous reflex with the corresponding muscle tone decreased.2.The abnormal rate of F-wave or H-reflex was71.7%which was higher han other items.3.The abnormal rate of compound muscle action potential(CMAP) and sensory nerve action potential(SNAP)(CMAP28.9%,SNAP44.4%)was higher than Nerve conduction velocity (MCV,SCV)delay and distal motor latency(DML)(MCV6.7%, SCV2.2%, MDML6.7%)4.The delay of Brain white matter myelinization and periventricular leukomalacia has correlation with Nerve conduction velocity (MCV, SCV)delayConclusionsThe abnormal rate of peripheral nerve conduction function is high in Children with cerebral palsy,yet typical clinical manifestations are not typical, it’s easier to be misdiagnosed.F-wave and H-reflex may be the sensitive items to find peripheral neuropathy in children with cerebral palsy。Peripheral neuropathy may locate in the proximal end of peripheral nerve or Spinal cord ventral horn.Axonal degeneration is more often seen than myelinization.The children with Brain white matter myelinization delay and periventricular leukomalacia may have problems with peripheral nerve myelinization.