The Application Study Of Nerve Electrophysiology Technology In The Early Diagnosis Of Diabetic Peripheral Neuropathy

ObjectiveTo evaluate the application value of three kinds of nerve electrophysiology technologies including quantitative temperature testing (QTT), sympathetic skin response (SSR) and nerve conduction velocity (NCV) in the early diagnosis of diabetic peripheral neuropathy(DPN).Materials And Methods85 diabetics were measured for quantitative temperature testing(QTT), sympathetic skin response (SSR) and nerve conduction velocity (NCV), QTT including four kinds of parameters including cold detection threshold (CDT), warm detection threshold (WDT), cold pain threshold (CPT) and heat pain threshold(HPT). After the end of all kinds of neural electrophysiological examinations, the results were statistically analyzed.Results1. The abnormal rates of QTT, SSR and NCV in selected diabetics were 84.71%, 56.47% and 31.76% respectively. The abnormal rate of QTT was significant higher than SSR and NCV, the difference were significance(P<0.05), the abnormal rate of SSR was higher than NCV(P<0.05), the difference was significance(P<0.05).2. The abnormal rates of QTT with asymptomatic group and symptomatic group were 78.85% and 93.94% respectively, there was no statistically significant difference between the groups(P>0.05). The abnormal rates of SSR were 48.08% and 69.70% respectively, the abnormal rates of NCV were 19.23% and 51.52% respectively, there were statistically significant difference between the groups(P<0.05).3. The abnormal rates of QTT with short course group and long course group were 77.77% and 89.80% respectively, there was no statistically significant difference between the groups(P>0.05). The abnormal rates of SSR were 44.44% and 65.31% respectively, the abnormal rates of NCV were 19.44% and 40.82 % respectively, there were statistically significant difference between the groups(P<0.05).4. The abnormal rates of CDT, WDT, CPT and HPT in selected diabetics were 51.76%,65.88%,37.06% and 41.76% respectively. The abnormal rates of WDT was higher than CDT, and the abnormal rates of CDT was higher than CPT, the difference was significance(P<0.05), the abnormal rates of HPT was higher than CPT, and the abnormal rates of CDT was higher than HPT, the difference was no significance(P>0.05).5. The abnormal rates of CDT, WDT, CPT and HPT in upper limbs were 44.71%, 57.65%,31.76% and 36.47% respectively, in lower limbs were 58.82%,74.12%, 42.35% and 47.06% respectively. The abnormal rates of CDT and WDT in lower limbs were higher than in upper limbs, the difference were significance(P<0.05), the abnormal rates of CPT and HPT in lower limbs were higher than in upper limbs, the difference were no significance(P>0.05).6. The abnormal rates of CDT, WDT, CPT and HPT in asymptomatic group were 40.38%,51.92%,32.69% and 39.42% respectively, in symptomatic group were 69.70%, 87.88%,43.94% and 45.45% respectively. The abnormal rates of CDT and WDT in symptomatic group were higher than in asymptomatic group, the difference were significance(P<0.05), the abnormal rates of CPT and HPT in symptomatic group were higher than in asymptomatic group, the difference were no significance(P>0.05).7. The abnormal rates of CDT, WDT, CPT and HPT in short course group were 41.67%,52.78%,38.89% and 43.06% respectively, in long course group were 59.18%, 75.51%,35.71% and 40.82% respectively. The abnormal rates of CDT and WDT in long course group were higher than in short course group, the difference were significance(P<0.05),the abnormal rates of CPT and HPT in long course group were lower than in short course group, the difference were no significance(P>0.05).ConclusionComparison with QTT, SSR and NCV, the abnormal rates of QTT is the highest of electrophysiological methods in the detection of diabetic peripheral neuropathy, the abnormal rates of QTT is not related with clinical symptoms and course, the abnormal rates of SSR and NCV are related with clinical symptoms and course. Cold detection threshold (CDT) and warm detection threshold (WDT) are the sensitive indexs for diagnosis of DPN. Nerve in lower limbs were easier injured in temperature sense than in upper limbs of DPN, warm sensory is main of injured.