Study On Genetic Variants Of Young Adluts With Self-injury Behavior

Objective To investigate the relationship between53SNPs in15candidate genes (or combining social demographic factors) and young adultswith self-injury behavior.Methods We got DNA from the bloods of242subjects (125youngadults with SIB and119healthy young adults as control). We profiled all thesubjects for DSM-IV Axis I psychiatric diagnosis.53SNPs from15candidate gene（sHTR1A, HTR2A, HTR1B, SLC6A4, TPH1, TPH2, BDNF,NTRK2, NGFR, CRHR1, CRHBP, CREB1, FKBP5, SLC1A3, GRIA3weregenotyped. Genesky Biotechnologies Inc. performed the genotyping. Weused Chi-square test to analyze the association between genetic variants,social demographic factors and SIB. We used Logistic regression analysis toevaluate the contribution of gene-social demographic factors to SIB.Results1. The distribution of gender, psychiatric history, mooddisorder history and family history of mental disorder, were different in thecase and control group (P<0.05).2. The genetic variants in rs7728378(CRHBP gene), rs11140800(NTRK2gene) and rs1147198(NTRK2gene) were related to young adults’ SIB.3. Cooperating with gender or family history of psychiatric disorder,the polymorphisms of rs1042173(SLC6A4) and other eighteen SNPs playeda protective or risk effect for SIB.Conclusion Preliminary findings suggest that allelic variability ofrs7728378（CRHBP）and other eighteen SNPs in nine genes referred to maybe relevant to the underlying diathesis for SIB.