Study Of Plasma Homocysteine Concentrations And Serum Folate, VitB12Concentration In Patients With Cerebral Infarction And Vascular Cognitive Impairment

Objective: To investigate the relationship between plasma homocysteine(Hcy) levels,serum concentrations of folic acid with VitB12and cerebral infarction cognitivedysfunction.Methods: According to the modified TOAST classification, the selected70patientswith acute cerebral infarction were divided into two groups including atherothrom-bossis(AT) and small artery disease(SAD). Moreover,35normal cases were selected asa control group. All the experimental cases were exsanguinated from cubital vein inlimosis and the levels of plasma Hcy, serum folic acid, VitB12, low-densitylipoprotein(LDL) and triglycerides(TG) were examined. Simultaneously all theincluded cases were evaluated by the Chinese version of the Montreal CognitiveAssessment (Montreal Cognitive Assement,MoCA).Results:⑴:The levels of plasma Hcy were16.820±2.096μmol/L,16.360±1.897μmol/L and10.194±1.894μmol/L for AT group, SAD group and control grouprespectively (F=95.822, P﹤0.05). The differences of plasma Hcy levels betweencontrol group and AT group as well as SAD group were significant (P<0.05), while theplasma concentrations of Hcy between AT group and SAD group were not significantlydifferent (P>0.05).⑵:The scores of AT group, SAD group and control group by MoCAwere21.77±1.66,21.74±1.65,27.63±1.11respectively (F=77.878, P﹤0.05). The differences of scores between control group and AT group as well as SAD group weresignificant (P<0.05), but the scores of AT group and SAD group were not significantlydifferent (P>0.05).⑶:The correlation index values (r) of plasma Hcy levels and scoresby MoCA were-0.823(P<0.05),-0.765(P<0.05) and-0.154(P>0.05) for AT group,SAD group and control group respectively.⑷:The r values between the levels ofplasma Hcy and serum VitB12were-0.477(P<0.05),-0.532(P<0.05) and-0.550(P<0.05) for AT group, SAD group and control group respective-ly.⑸:The r valuesbetween the levels of plasma Hcy and serum folic acid were-0.579(P<0.05),-0.654(P<0.05) and-0.658(P<0.05) for AT group, SAD group and control group respectively.⑹:The r values between the levels of serum folic acid and scores by MoCAwere0.423(P<0.05),0.428(P<0.05) and0.014(P>0.05) for AT group, SAD group and controlgroup respectively.Conclusions:⑴:Both the plasma Hcy levels of AT and SAD patients are much higherthan that of normal people, while the differences of plasma Hcy concentrations in ATand SAD patients are not significant.⑵:Both the scores of AT and SAD patients byMoCA are significantly higher than that of normal people, but the differences of scoresfor AT and SAD patients are not apparently. Furthermore, the plasma Hcy levels arenegatively correlated to scoring by MoCA in both AT and SAD patients, while notassociated with scoring in normal people.⑶:The levels of plasma Hcy are negativelyrelated to the levels of serum VitB12and folic acid in both AT, SAD patients andnormal people.⑷:The levels of serum folic acid have positive relations to scoring byMoCA in both AT, SAD group but have no relation to scores by MoCA in controlgroup.