Study On The Correlation Of Mild Cognitive Impairment With Insomnia And Observe The Efficacy Of Intervention By Qingnao Fushen Ye

Object:Mild cognitive impairment (MCI) is a kind of syndrome in the elderly population, about9.9%of the total population has this sickness, and there are many reports about the etiology and treatment of MCI. On one hand, this study was to investigate the effect of insomnia to MCI incidence, and elucidate the risk factors in the elderly with MCI through the correlation of insomnia and MCI. On the other hand, through observing the clinical curative effect of the intervention to MCI insomnia and kidney phlegm by Qingnao Fushen Ye, we want to provide new ideas and methods for the prevention and treatment of MCI.Methods:1. From October of2012to February of2013, we collected56MCI patients at the life community of south train station in Chengdu and the Chengdu University of TCM hospital’s outpatient, included24MCI patients and32MCI with insomnia patients. Compared the cognitive function assessment scale (include CMSMMSE, ADL, HIS, GDS and so on) of those two groups, analysis of the statistical methods to explore the correlation of insomnia and MCI.2Using self-controlled method to those32MCI with insomnia patients, observing the various neuropsychological scale, insomnia curative effect and TCM syndrome curative effect after taking Qingnao Fusheng Ye12weeks, and using of statistical correlation analysis method, and compared before and after the treatment scale score and therapeutic effect of syndrome.Results:1. There were statistically significant of scale integral between those two groups’ MMSE, CMS, ADL, GDS, CDR, HIS and so on (p<0.05). The MCI with insomnia patients’ cognitive level was significantly lower than MCI patients.2. There were statistically significant of scale integral between before and treatment of patients’ MMSE, CMS,ADL, GDS, CDR, HIS and so on(p<0.05). Before and after treatment in TCM symptoms integral were significantly different (p<0.05), the total effective rate of TCM syndromes was96.8%, the total effective rate of insomnia was93.7%, that’s a significant effect.3, None of adverse reactions and side effects were observed during clinical trials in those two groups, laboratory tests of two groups showed no abnormal changes, it shows that those medicines have no significant side effects.Conclusion:1. there are some correlation between insomnia and MCI, Insomnia may be an important risk factor for decline MCI cognitive level, We can find a new idea and new method to treat MCI from intervention of insomnia.2Using Qingnao Fusheng Ye to intervened in the treatment of patients with MCI associated with insomnia has significant effect, and stability and recovery of cognitive function to improved sleep quality and cognitive function has the remarkable effect, and fewer adverse reactions, high security, is worthy of clinical use.