Clinical Analysis Of60Cases Diagnosed Bilateral Breast Cancer

Background and Objective:Breast cancer has become one of the most common tumorsin women, incidence of bilateral breast cancer increased gradually in recent years.Domestic researchs of bilateral breast cancer,however, are less and conflict.This studywas undertaken to determine the differences in the clinicopathology, molecular typing,treatment and prognosis between metachronous and synchronous bilateral breast cancer,bilateral breast tumor on both sides.Materials and methods:5120cases of collection of General Surgery in the FirstAffiliated Hospital of Dalian Medical University between January1992and March2013which were diagnosed of breast cancer patients, which confirmed60cases ofbilateral primary breast cancer over the same period accounted for1.17%. SPSS18.0software was used for statistical analysis, the application of chi-square test, rank sumtest, log-rank test for count data analysis, Kappa test analysis for the consistency ofbilateral breast cancer ER, PR and HER-2expression, survival analysis was performedusing Kaplan-Meier method and Log Rank test was used to compare the outcome ofdifferent groups, P<0.05was considered statistically significant.Result: Bilateral primary breast cancer of60cases, accounting for1.17%of all breastcancer in the same period, while a total of13cases of synchronous bilateral breastcancer, accounting for21.7%of all bilateral breast cancer,47cases of metachronousbilateral breast cancer, accounting for78.3%of all breast cancer. Between synchronousbilateral breast cancer and metachronous breast cancer, the difference of age whenprimary cancer was dignosed was statistically significant (P=0.041). The difference ofprimary cancer case with menopause was not statistically significant (P=0.50). Thefamily history was no significant difference (P=0.50). The diference of histologicaltype in synchronous breast cancer between two sides of bilateral breast cancer wasstatistically significant (P=0.033). The pathological type in metachronous bilateralbreast cancer was no significant difference between the first primary tumor and contralateral tumor(P=0.674). In metachronous bilateral breast cancer the differencebetween first primary tumor diameter size and the second primary tumor wasstatistically significant (P=0.001). The staging difference between the first and secondprimary tumor of metachronous bilateral breast cancer was not statistically significant(P=0.788). The difference of the first primary tumor pathological staging betweensynchronous and metachronous bilateral breast cancer was statistically significant(P=0.014). The difference of the second primary tumor pathological staging betweensynchronous and metachronous bilateral breast cancer was statistically significant(P=0.010).Conclusion:1. The age of primary cancer in matechronous bilateral breast cancer isearlier than in the synchronous bilateral breast cancer, tumor diameter of contralateralbreast cancer is much smaller than the primary diameter in matechronous bilateralbreast cancer. The pathological staging of synchronous bilateral breast cancer both infirst primary tumor and the second primary tumor is earlier than metachronous bilateralbreast cancer.It demonstrate patient after breast cancer should be closely followed,whichcan improve the early detection rate of contralateral breast cancer.2. The synchronous bilateral breast cancer lesions on both sides of ER, PR,Her-2havegood consistency and matechronous bilateral breast cancer lesions on both sides of ER,PR, Her-2have poor consistency. The consistency of primary cancer molecularclassification between synchronous and metachronous breast cancer is poor.bilateralbreast cancer first primary cancer can predict immunohistochemistry ofcontralateral,but it is unpridictive of the long interval BPBC patients.3.In this study, survival analysis showed that age at menarche, regional lymph nodes isthe impact of bilateral breast cancer survival and prognosis of non-independent riskfactors.The menarche age≤14years old had a better prognosis than those over theage of14. Regional lymph node without metastasis in patients with a better prognosisthan metastasis.4. Multivariate Cox regression analysis showed that the interval is an independent riskfactor affecting bilateral breast cancer prognosis. The prognosis of synchronous bilateralbreast cancer is worse than metachronous bilateral breast cancer, and the shorter the...