Metastasis And Survival Status And Related Factors Anayses For Postoperative Bilateral Primary Breast Cancer

[Objective]To explore risks of metastasis and death and their related factorsfor postoperative Bilateral Primary Breast Cancer.[Methods]222 patients diagnosed with BPBC, received the surgical operationin Tianjin Medical University Cancer Hospital from March 1972 to December2003 were recorded and survival and metastasis status were followed up.Kaplan-Meier method was used for the survival analyses and the same methodand Cox regression were used for the prognostic factors analyses.[Result]1. Multivariate analysis finds that size of secondary side cancer andtwo sides positive lymph node are associated with survivalprognosis, secondary side positive lymph node, size of secondaryside cancer and mammary disease history are associated withmetastasis prognosis.2. The patients with mammary disease history and the age of firstbirth more than 25 years metastasize easily.3. The patients whose interval between the primary breast cancer andthe second one is less than 24 months have worse survival prognosisthan those more than 24 months.4. The survival and metastasis prognosis of patients with positivelymph node of anyone side are worse than those with negative lymphnode.5. The survival and metastasis prognosis of patients with size ofsecondary cancer＞5cm is worse than those with cancer size≤5cm. 6. The survival and metastasis prognosis of patients with histologygrade 3 of secondary cancer is worse than those with histologygrade 1-2.7. After operation for the secondary cancer of breast, the 3-year5-year and 10-year Cumulative Survival rates of BPBC were 87.04%,78.73% and 69.09%, respectively. The 3-year 5-year and 10-yearCumulative metastasis rates of BPBC were14.30%, 19.39%, 30.53%,respectively.[Conclusion]Single factor analyses show that three factors are related to badsurvival and metastasis prognosis which is positive lymph node of twosides, cancer size＞5cm and histology grade 3 of secondary cancer.Multivariate analysis finds that survival prognosis factors aresize of secondary side cancer and positive lymph node of two sides,metastasis prognosis are positive lymph node of secondary side, cancersize of secondary side and mammary disease history.The findings that the patients with mammary disease history andwhose first birth age is more than 25 years old have bad metastasisprognosis, and the patients whose interval between the primary breastcancer and the second one is less than 24 months have worse survivalprognosis than those more than 24 months are the first time to be reported.