Type2Diabetes Cases-case-control Study Of Risk Factors Associated With Osteoporosis

Objective: By comparing the differences of risk factors between type2diabetespatients with osteoporosis and those patients without osteoporosis to test theassociation of risk factors for type2diabetes with osteoporosis, to provide scientificbasis to prevent the development of diabetes with osteoporosis, to reduce the risk offractures caused by diabetes osteoporosis and the burden of families of patients, toimprove the quality of life of diabetes patients.Methods: Based on epidemiological studies of the risk of complications ofChinese patients with type2diabetes, using cluster sampling method to screen Type2Diabetes in the community of Dalian. Data were obtained by questionnaires, physicalexamination, routine biochemical status of glucose metabolism and the oral glucosetolerance test, etc.. Then we randomly selected638patients with type2diabetesdiagnosed in men ages over60and postmenopausal women to test bone mineral density,A cases-case-control study was used to test the association between type2diabetespatients with osteoporosis. Those patients diagnosed as type2diabetes with abnormalbone mineral density (decreased bone mineral density and osteoporosis) were selectedas the case group, while those patients without abnormal bone density as a control group.A database was set up using Epidata software and the statistical analysis wereconducted by SPSS13.0software. Statistical methods such as t test, chi-square test andsingle factor non-conditional logistic regression analysis were used as single factoranalysis, multivariate unconditional logistic regression model analysis of risk factorswas choused for multivariate analysis.Result: Among638cases of type2diabetic patients,319patients diagnosedabnormal bone mineral density (decreased bone mineral density+osteoporosis),25.7%of men (82/319),74.3%of women (237/319),319cases without abnormalbone mineral density, male32.9%(105/319), female67.1%(214/319). Univariate analysis indicated that age, female menopause, waist-to-hip ratioshowed a significantly difference between case and control groups, the average age ofthe case group is older than the control group, female menopause longer is a risk factorof osteoporosis, higher waist-to-hip ratio is a risk factor of abnormal bone mineraldensity. Other factors such as ethnicity, education level, occupational history ofexposure to harmful substances, eating habits, lifestyle factors, biochemical parameters,medical history, etc. did not show significant differences between case and controlgroups.Those factors that showed a significant differences between case and controlgroups and those factors that commonly were considered may be related to the risk oftype2diabetes with osteoporosis were selected to perform a multivariate logisticregression analysis. The results showed that elder people, women, larger waist-to-hipratio were risk factors of diabetes with abnormal bone density, tea drinking is aprotective factor of bone mineral density.Conclusion: Elder people, larger waist-to-hip ratio, women with diabetessignificantly increased the risk of type2diabetes with osteoporosis, while tea drinkingsignificantly decreased the risk of type2diabetes with osteoporosis. Some preventivemethods should be carried out such as primary prevention, early diagnosis, etc., toreduce the risk of occurrence of the diabetes with osteoporosis, to improve the quality oflife of diabetes mellitus.