| Objective:Thisresearchaimsatclearingheat-toxicitycollateralsinWangbi(rh eumatoidarthritis)beforeandafterthetreatmentofdamp-heatBizuandinterleukinl (IL-1), clinicaleffectsofESR, CRP, RF, antiCCPantibodylevels, ofWangbiTCMdampness detoxificationTongluo(rheumatoidarthritis)mechanismofdamp-heatBizutreatment effectandactivestageofrheumatoidarthritis.Methods:FuturefromAffiliatedHospitalofChangchunUniversityofTraditionalC hineseMedicine, Departmentofrheumatismof60outpatientandhospitalizedpatients, dividedintotreatmentgroupandcontrolgroup. Thetreatmentgroup:30cases, takingtr aditionalChinesemedicinedecoctionplusleflunomidetablets;thecontrolgroup:30c ases, takingtheaceclofenac+leflunomidetablets. lmonthsofcontinuoustreatmentof1courses, lcourseswereobserved. Theobservationgroupandthegroupoftreatmentofin terleukininserumofpatientswithandl(IL-1), ESR, CRP, RFchange, CCPantibodyandthe clinicalcurativeeffectindex(jointpain, jointswelling, jointtenderness, adverse jointflexionetc)thedegreeofimprovement, atthesametime, thecomparisonbetweenth etwogroupscurativeeffectdifference.Results:1. ThetreatmentgroupandthecontrolgroupbeforeandaftertreatmentofTCMsyndro me, tenderjointcount, swollenjointcount, morningstiffness, strength, jointpain, h ealthevaluationscoreweresignificantlydifferent(P<0.05).2. Therewassignificantdifferencebetweenthescoreoftreatmentgroupandcontro lgroupofChinesemedicinesymptom, tenderjointcount, swollenjointcount, morningst iffness, strength, jointpain, health, IL-1, ESR, CRP(P<0.05). ThescoresofRF, antiCC Pantibodyandtheefficacybetweenthetreatmentgroupandthecontrolgrouphadnosigni ficantdifference(P>0.05).3. Thetreatmentgroupandthecontrolgroupbeforeandaftertreatment, IL-1, ESR, C RP, RF, antiCCPantibody(contrasteffectformula?)P<0.05, hadstatisticalsignifica 4. ThetreatmentgroupandthecontrolgroupIL-1, ESR, CRP, RF, antiCCPantibody (co ntrasteffectformula?)P<0.05, hadstatisticalsignificance.5. Thetreatmentgroupandthecontrolgroupofdiseaseactivity(DAS28)effectanal ysis(formula?)P<0.05, hadstatisticalsignificance.6. Thetreatmentgroupandthecontrolgroupofdiseaseactivity(ACR)effectanalys is(formula?)P<0.05, hadstatisticalsignificance.Conclusions:Aftertheclinicaltrialshowthat, QingrejiedudampnessTongluoofW angbi(rheumatoidarthritis)effectofdamp-heatBizusignificantly, andnoobviousad versereactionsandsideeffects, thedrugtreatmentofrheumatoidarthritisissafeand effective, thevalueofclinicalresearchanddevelopmentwithhigh. |