Expression Of Fascin Protein In The Colorectal Tumor And Its Clinical Significance

Objective:1. Test the expression of fascin protein in colorectal cancer, adenoma and normalepithelial tissue.To investigate the role of the fascin protein in the process of thecolorectal cancer2. Analyze the relationship between fascin protein expression in different tissuesand pathologic data.To investgate the relationship of fascin protein and colorectalcancer biology behavior.3. Find new target spot for colorectal cancer treatment and provide laboratorybasis.Method:The fascin protein expressions in45cases of colorectal cancer tissues,20casesof colorectal adenoma tissues and10cases of normal epithelial tissue were detectedby using the immunohistochemistry (IHC) EnVision method. Furthermore,corresponding clinical data was collected, including gender, age, blood type, tumorlocation (rectal cancer and colon cancer) as well as tumor staging, grade andlymphatic metastasis. Finally, these collected clinical data were analyzed throughSSPS13.0and their relationship with fascin protein expression was analyzed.Results:1. Among the45cancer cases,25were detected with positive expression,occupying55.5%and4of the20adenoma cases were detected with positiveexpression, occupying20.0%. No positive expression was observed in the cut normallarge intestine tissue, P=0.007.2. The expression of fascin protein is unrelated with patients’ gender (P=0.893),age (P=0.202), blood type (P=0.865) and tumor anatomical location (P=0.396), butrelated with patients’ neoplasm staging (P=0.019), grade (P=0.014) and lymphaticmetastasis (P=0.019). Generally, fascin protein expresses in diffuse deep dyeing incancer and focal dyeing in adenoma. Conclusion:1. Fascin protein finds no expression in normal epithelium, low expression inadenoma and high expression in cancer, indicating that it may participate in theoccurrence of colorectal neoplasms and play an important role in the progress ofcolorectal cancer.2. Fascin protein is unrelated with age, gender, blood type and tumor location,but related with neoplasm staging, grade and lymphatic metastasis, indicating thepositive correlation between fascin protein and tumor invasiveness.3. Fascin protein can be taken as a new target spot of treatment.