The Study Of The Relationship Immune Globulin J Chain With TCM Type Of Symptoms Of Liver Fibrosis Degree About Chronic Virus Hepatitis B

Subject:By using clinical liver fibrosis indexs to analysis chronic hepatitis B (CHB) with Internal Stasis of Dampness and Heat Syndrome (I), Depressed Liver With the Insufficient Spleen Syndrome (II), Liver and Kidney Yin deficiency Syndrome (III), the Spleen and Kidney Yang deficiency Syndrome (IV), Collateral Obstruction by Blood Stasis Syndrome (V) five syndromes and healthy controls (VI) of liver fibrosis degree increasing. At the same time, by using enzyme-linked immune detection technology (ELISA) to detect immunoglobulin (Ig-J) J chain content in peripheral blood plasma of CHB five syndromes. Looking for the relationship between Ig-J with the TCM syndromes of liver fibrosis degree about CHB, in order to seek to a certain value of the objective quantitative indicators which will be used to determine the liver fibrosis degree in protein molecular level about CHB each syndrome. Finally, to alleviate and block the liver fibrosis process effectively, and to reduce the incidence of liver cirrhosis in clinical work, and to provide reference for improving the clinical curative effect of CHB objective basis. Methods:According to the "Hepatitis TCM standards", in Luzhou Medical College Affiliated Hospital of TCM outpatient and hospitalization in patients with CHB in February2012-the October2012. Selecting typical cases with Internal Stasis of Dampness and Heat Syndrome, Depressed Liver With the Insufficient Spleen Syndrome, Liver and Kidney Yin deficiency Syndrome, the Spleen and Kidney Yang deficiency Syndrome, Collateral Obstruction by Blood Stasis Syndrome five kinds of Chinese medicine syndrome patients as the observation group from these cases were150cases to healthy controls15cases of the control group. Using ELIS A to detect the contents of Ig-J, and collected the results about the four specimens of liver fibre, imaging examination (abdominal pa) and liver function (globulin) at the same time. Comprehensive the content of Ig-J, liver fiber four, abdomen colour to exceed, globulin of various syndrome group and the healthy controls to analysis the relationship between Ig-J content and the degree of hepatic fibrosis of CHB. Measurement data with the (x+S) said, with the single factor analysis of variance and SNK-q statistical analysis, all data in the computer by SPSS v11.5statistical software. Results:(1)CHB five syndromes of liver fiber four sorts for (content from high to low):HA:Ⅴ> Ⅲ≥Ⅳ>Ⅱ>Ⅰ≥Ⅵ(note:">" said adjacent to compare differences between the two groups have statistical significance (p<0.05or p<0.05);"≥" said adjacent comparative differences between the two groups has no statistical significance p>0.05); PCⅢ:Ⅴ> Ⅲ> Ⅳ>Ⅱ>Ⅰ≥Ⅵ; LN: Ⅴ> Ⅲ≥Ⅳ>Ⅰ>Ⅱ>Ⅵ; PⅣ:Ⅴ> Ⅲ≥Ⅳ>Ⅰ>Ⅱ>Ⅵ.(2) Imaging examination of CHB five syndromes (abdomen colour to exceed) fibrosis degree from heavy to light, the semi-quantitative score ranking is:≥Ⅵ. Portal vein diameter (from wide to narrow) sort of:Ⅴ> Ⅳ> Ⅲ>Ⅱ> Ⅰ≥Ⅵ.(3) Globulin sort of CHB five syndromes (content from high to low):Ⅴ>Ⅲ≥Ⅳ>Ⅱ≥Ⅰ≥Ⅵ.(4) By comparing the Ig-J syndrome group and healthy normal levels, including five blood stasis blocking collaterals group than other groups obviously on the high side, the sort of content (from high to low):Ⅴ>Ⅲ> Ⅳ>Ⅱ≥Ⅰ≥Ⅵ. Conclusions:(1) According to four, imaging examination, liver fiber (pa/belly) and globulin, according to the result of the CHB five syndromes and normal order degree of liver fibrosis (from heavy to light):Ⅴ,Ⅲ, Ⅳ,Ⅱ, Ⅰ,Ⅵ.(2) By ELISA test results, the content of Ig-J in CHB five syndromes and normal order (from high to low):Ⅴ,Ⅲ, Ⅳ,Ⅱ,Ⅰ, Ⅵ. The conclusions are consistent with (1) the basic.(3) The extent of fibrosis in patients with CHB is heavier, the peripheral blood plasma Ig-J had higher content of Ig-J expression increases with CHB five syndromes of liver fibrosis degree of increase is consistent, there is a positive correlation between them. This prompts us, clinical can be through the detection of Ig-J content, combined with liver fiber four, abdomen colour to exceed, globulin preliminary judgment CHB five syndromes of liver fibrosis degree, whether in CHB treatment resistant fiber treatment for clinical provides the objective basis.