Study On The Correlations Between The Indexes Of Hepatic Fibrosis And The Syndrome Types Of TCM Of Liver Cirrhosis After Hepatitis B

Objective: By measuring the blood serum indexes of hepatic fibrosis in patients with liver cirrhosis after hepatitis B: HA (hyaluronic acid).PCIII(blood serum procollagen III).IV-C (collagen IV) to explore the connection of the syndrome types of TCM, the indexes of hepatic fibrosis and Child-Pugh index grading.Method: Collect the complete Chinese medicine clinical data in patients with liver cirrhosis after hepatitis B cases of information, combined with indexes of hepatic fibrosis and Child-Pugh liver function prognosis graduation and syndrome differentiation, for the collation of data collected, the continual variable value by the mean value±standard deviation ( (x|-)±s) indicated that during many groups measures the material comparison to use the variance analysis and the q test.Results: In 77cases,the liver qi depression are 19 cases, accounts for 24.7%; followed by spleen deficiency to damp accumulated 15 cases , damp-heat accumulates insides heat 15 cases and blood stasis 11 cases, with respective shares of 19.5%, 19.5% and 14.3%; The liver-kidney yin deficiency and spleen-kidney yang deficiency are 9 and 8 cases, accounting respectively for 11.7% and 10.3%.The liver qi depression and spleen deficiency to damp accumulated types are primary in Child-Pugh A level, accounts for 84.2% and 60.0%, the liver qi depression and spleen deficiency to damp accumulated have the remarkable differences comparing with damp-heat accumulates insides heat, liver-kidney yin deficiency, spleen-kidney yang deficiency and blood stasis type (P<0.05), not find patients in Child-Pugh C; The damp-heat accumulates insides heat is primary in Child-Pugh B level, accounts for 66.7%, has the remarkable difference comparing with other types (P<0.05);The liver-kidney yin deficiency, spleen-kidney yang deficiency and blood stasis type are primary in Child-Pugh C level, accounts for 55.6%, 50%, 54.5% respectively, has the remarkable difference comparing with liver qi depression, spleen deficiency to damp accumulated and damp-heat accumulates insides heat(P<0.05).The HA target level in various types height order is: liver qi depression< spleen deficiency to damp accumulated < damp-heat accumulates insides heat< blood stasis type < spleen-kidney yang deficiency < liver-kidney yin deficiency, The liver qi depression and spleen deficiency to damp accumulated have the remarkable differences comparing with damp-heat accumulates insides heat, blood stasis type, spleen-kidney yang deficiency and liver-kidney yin deficiency (P<0.01). The PCIII target level in various types height order is: spleen deficiency to damp accumulated < liver qi depression0.05).Conclusion: The liver qi depression and spleen deficiency to damp accumulated are commom in Child-Pugh A, while damp-heat accumulates insides heat in Child-Pugh B; And blood stasis, liver-kidney yin deficiency and spleen-kidney yang deficiency are commom in Child-Pugh C. The TCM Syndrome Types combining with Child-Pugh classification have some meaning to disease prognosis.The process of liver fibrosis is varies with the different types, different types reflect the degree of severity of liver fibrosis in some way. HA can be used as TCM Syndrome Types of liver cirrhosis to determine one of the better target.HA is correlated with the severity of liver cirrhosis, which can be as Child-Pugh classification of a reference target, and it is closed with Child - Pugh index grading.