| Objective To investigate the expression of RIN1in breast cancer, andanalyze its association with the prognosis.Methods To analyze the tissues of85breast cancer and20benignbreast disease patients by immunhistochemical techniques, and followed upthe85cases of breast cancer; RIN1in20cases of breast cancer andadjacent tissues’ expressions by Real Time PCR and Western blot assay.Kaplan–Meier survival analyze the average survival time.Results A varying degrees of RIN1were expressed in85cases of breastcancer,high expression in44cases,RIN1was highly expressed in breastcancer than in no-cancer tissues (p﹤0.05);The expression of Rasinteraction/interference1were extremely associated with tumor size、histological grade、family history (p﹤0.05). the average survival time ofhigh-expression group was extremely shorter than low-expression one(p﹤0.05).The high expression of RIN1was related to the tumor disease-freesurvival (p﹤0.05). The expression of RIN1mRNA and its proteinsignificantly increased in cancer tissues than its adjacent tissues in20couple of cases. Conclusion The expression of Ras interaction/interference1played arole in breast cancer pathogenesis and Maybe the high-expression may beused as a prognostic marker of breast cancer. |
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