Correlation Of Cartilage Oligomeric Matrix Protein Associated With Osteoarthritis And Clinical Significance

Objective: To research whether COMP associated with osteoarthritis progression,and whether it has clinical value for the early diagnosis of KOA by measuring COMPlevel.Methods: To manufacture the KOA model by Improved Hulth method; to observethe changes of DR of model during different time; to detect the level of serum COMPof model by ELISA during different time, using T test to making correlation analysis.Results:①Improved Hulth method could be successfully replicated arthritis modelof the early, middle and late;②the control groups: the level of serum COMP wasrespectively3.287±0.265、3.261±0.273、3.292±0.251、3.252±0.259in before building,two weeks, six weeks and ten weeks, There was no statistically significant differencesin each stage(average>0.05);③t he experimental group:the level of serum COMPwas respectively3.300±0.126、3.695±0.144、4.093±0.156、3.814±0.162, There arestatistically significant of comparative differences between groups and within thegroup(average<0.01).Conclusions:①Improved Hulth method can successfully replicate rabbit animalmodel of KOA;②COMP associated with osteoarthritis progression;③COMP hasauxiliary value for the early diagnosis of KOA, but as the "gold standard" of thediagnosis research needs to be continued...