Clinical Study Of Ashen Yihao Capsule With Buspirone On The Treatment Of Generalized Anxiety Disouder

Objective：To investigate clinical efficacy of anshen yihao capsule with buspirone totreat the generalized anxiety disorder and its effect on cortisol levels.Methods：To divide63generalized anxiety disorder patients that meet the inclusioncriteria randomly into two groups:(Chinese and Western medicine group),32cases, and thecontrol group (Western medicine group),31cases. The treatment group received: buspirone,10mg each time, twice a day orally; Anshen yihao capsule, four pills each time, three times aday. The control group received: buspirone,10mg each time, twice a day orally. Both last4weeks. The comparison for age, gender, the course of the disease and other basic informationbetween the two teams before treatment showing that there is no statistics difference, whichmeans the two teams are comparable. Record the condition before the treatment and2and4weeks after. The clinical efficacy of treatment is based on TCM symptom scale, HAMA andchanges in plasma cortisol concentration. The side-effects are accessed by TESS. The finallyscore is got by statistical methods, which can evaluate the effectiveness of the joint treatmentof generalized anxiety disorder and the possible mechanism.Results:(1) The HAMA scores of two teams2weeks after the treatment decreased thanbefore, while the treatment group decreased more significantly. Two groups weresignificantly different (P<0.05), which had statistical significance. After4weeks, bothHAMA scores decreased apparently, but the treatment group claimed to be better than thecontrol group. Two groups were significantly different (P<0.05).2weeks after the treatment,the treatment group recovered5cases, excellent17cases, effective3cases, non-effective2cases, total effective rate83.3％,while the control group recovered0cases, excellent10cases,effective12cases, non-effective8cases, total effective rate73.3％. Two groups weresignificantly different in the clinical efficacy (P<0.05), which meant the treatment groupperformed better than the control group.(2)2weeks after the treatment, TCM symptom scaleof the two teams were significantly different(P<0.05), the results after4weeks were the same,which meant the treatment group claimed to be better than the control group. Comparison ofthe efficacy of traditional Chinese medicine:2weeks after the treatment, the treatment grouprecovered6cases, excellent15cases, effective3cases, non-effective6cases, total effective rate80％,while the control group recovered0cases, excellent6cases, effective15cases,non-effective9cases, total effective rate70％, which meant the treatment group performedbetter than the control group.4weeks after the treatment, the treatment group recovered15cases, excellent10cases, effective4cases, non-effective1cases, total effective rate96.7％,while the control group recovered8cases, excellent12cases, effective5cases,non-effective5cases, total effective rate83.3％. Two groups were significantly different inthe efficacy of traditional Chinese medicine, which meant the treatment group performedbetter than the control group. Before the treatment two teams showed no significantdifference (P>0.05) in traditional Chinese medicine integral factors while significantly lowerafter treatment, showing significantly difference (P<0.05). After the treatment, both teamsshowed statistically significant (P<0.05) in chest pain, anxiety, nausea, anorexia andabdominal discomfort. The treatment group performed better than the control group inimproving symptoms. All other symptoms were improved, but comparison between groupswas not statistically significant(P＞0.05).(3) After treatment, two groups both can reduce theplasma cortisol level, while more apparent in treatment group. Comparison between groupswas statistically significant (P<0.05).(4)Comparison between the adverse reactions:treatment group didn’t appear adverse reactions while there were3dry mouth cases in controlgroup. There was a significant difference (P<0.05) between two groups of incidence ofadverse reactions（P<0.05）Conclusions:1. Clinical observation of the treatment of generalized anxiety disorder byjointing AnShenYiHao Capsule with buspirone was significant and was better than buspironeonly. It provided a fast onset of action and there were no adverse reactions.2. The influenceof the treatment of generalized anxiety disorder by jointing AnShenYiHao Capsule withbuspirone was different from that buspirone influenced cortisol levels. The former canapparently decrease cortisol levels.