The Clinical Analysis Of Singleton Pregnancies Complicated By Congenital Fetal Malformations

Objectivesto analyze the categorization, constituent ratio of all fetal anomalies, the relevant riskfactors and pregnancy outcomes in singleton pregnancy and to investigate the commontypes in order that we can provide some valuable evidence for singleton pregnancies ofhigh-risk malformation with genetic counseling, antenatal care and reasonabledetermination on pregnancy outcomes.Materials and methodsThis study recruited75cases of singleton pregnancies complicated by fetal malformationsand150controls hospitalized in the Tongji hospital of Huazhong university of science andtechnology over the period from2008to2012. all factors related to fetal malformationswere analyzed by binomial classification Logistic regression method in the software ofSPSS19.0. furthermore, we investigated the predict effects that Downs screening can haveon trisomy21and explored the pregnancy outcomes between the two contrast groups.Results （1）the configuration ratio of75singleton pregnancies complicated by fetalmalformations①Cardiovascular system fetal abnormalities whose percentage is22.67are the mostcommon type, with the multi-system being the second.②Ventricular septal defect whosepercentage is58.82most frequently develops in Cardiovascular system fetal deformitiesand Downs syndrome whose percentage is42.86is most common type of syndromemalformations.（2）Related factors of fetal malformations A hazard ratio of10multiplied risks of fetal malformations in pregnancies complicated by oligohydramnios isdiscovered compared to normal controls with the odds ratio and p value being18.843andzero respectively. At the same time, other factors such as polyhydramnios, ART, ect. hadlittle influence on the development of fetal malformations with the p value above0.05. （3）Downs syndrome and trisomy the risk of developing trisomy21in pregnancies withnomal Downs screening results was0.167times of that with high risks and thus the formercan have a decreased chance of83.3%developing trisomy21.（4）The abnormalgenetics of singleton pregnancies complicated by fetal malformations the geneticresults of5cases who had underwent genetic examination were as follows.60%(3cases)was trisomy21and certificated by antenatal chromosome checkout later;One Danly-walker syndrome, who had not underwent genetic examination was edemasyndrome; The last case whose paternal and maternal chromosome examination resultswere abnormal was diagnosed as carpopedal contraction.（5）The outcomes of singletonpregnancies In75fetal malformations cases,3neonates were liveborn with2deliveriedby cesarean section and the other70cases were all induced by acrinol. on the basis ofindependent-samples t test, the average gestational weeks when termination was carriedout between the two contrast groups were(26.64±5.82)W and (36.69±3.61) W respectivelywith the p value being0.000. The differences of gestational weeks when abnormalies werediscovered and terminated later among all classifications were insignificant with p valuesabove5.Conclusion（1）Cardiovascular system fetal deformities, of which the most common type isventricular septal defect, are the most common type of systemic malformations insingleton pregnancy and Downs syndrome and hydrops are the two most common types ofsyndrome malformations.（2） A hazard ratio of10multiplied risks of fetalmalformations in pregnancies complicated by oligohydramnios is discovered compared tonormal controls, however, with other factors such as polyhydramnios, ART, ect. had littleinfluence on the development of fetal malformations.（3）Trisomy21is the most commontype of chromosome abnormalities in fetal malformations. The forecast effects on trisomy21carried by Downs screening is good. the difference of average gestational weeks whentermination was carried out between the two contrast groups is significant. Whereas, the differences of gestational weeks when abnormalies were discovered and terminated lateramong respective classifications were insignificant.