Analysis Of Survival Rate And Influence Factors Of Operation In The Treatment Of Liver Cancer

Objective: Observe the survival of patients after the treatment of primary liver cancer surgery, and to explore theprognostic factors affecting the surgical treatment of primary liver cancer.Method: Retrospective analysis of the First Affiliated Hospital of Shihezi University medicalschool from2003January to2011December liver resection in126patients with clinical dataand follow-up data, and confirmed by pathology in primary hepatocellular carcinoma,selection may on hepatocellular carcinoma operation prognosis influence factors, includingsex, age, cirrhosis, hepatitis B surface antigen, tumor location, tumor size, tumor number,preoperative AFP, preoperative and postoperative changes in AFP, operation mode,Child-Pugh grade, vascular invasion, adjuvant therapy, pathological typing and other14variables. Survival analysis using the method of Kaplan-Meier, factors associated withLog-rank test, Cox model line multivariate analysis, screening out the factors affecting theprognosis of.Result:Follow-up to June30,2012,11patients (8.73%)were lost to follow,liver cancerpatients after1-,3-and5-year overall survival rates were84.3%,69.5%,39.4%, the mediansurvival time was50.14months, recurrence-free survival rates were66.2%,33.6%,21.4%.Univariate analysis showed that the tumor size, preoperative AFP, preoperative andpostoperative changes in AFP, vascular invasion, cirrhosis and adjuvant therapy is the impactof postoperative hepatocellular carcinoma prognostic factors (P<0.05), Cox multivariateanalysis showed postoperative AFP changes,vascular invasion,liver cirrhosis is anindependent prognostic factor affecting the survival of patients with hepatocellular carcinoma(P <0.05).Conclusion:1.Compared with other domestic hospitals,our overall survival in patients withhepatocellular carcinoma after operation hospital treatment rate is basically the sameï¼›2.Thedata showed that the prognosis factors of hepatocellular carcinoma after operation is affectedby many factors:tumor size,serum AFP,preoperative and postoperative changes ofAFP,vascular invasion, liver cirrhosis and liver cancer after adjuvant therapy is theinfluencing factors;2.Early and standard treatment, increasing the proportion of small livercancer operation and enhance postoperative AFP monitoring is the key to improve theprognosis of hepatocellular carcinoma operation;3.changes of AFP,vascular invasion andliver cirrhosis were independent prognostic factors.Preoperative and postoperative.