Uygur And Han Three-negative Breast Cancer Clinical Features, Prognosis And VEGF, EGFR Expression Difference Analysis

Objective: To compare the clinical characteristics and prognostic differences of UygurAnd Han triple-negative breast cancer (TNBC) patients, and analyze the expression of itsvascular endothelial growth factor (VEGF) and endothelial growth factor receptor (EGFR),and analyze the relationships between them, strive to provide individualized treatment fordifferent ethnic TNBC patients. Methods: From January2004to January2006,167caseswere admitted, selected from the Third Affiliated Hospital of Xinjiang Medical TNBCpatients met the inclusion criteria, a retrospective analysis of the clinical data were done,its Organization wax block using immunohistochemical method expression of VEGF,EGFR situation using SPSS17.0rank sum test and Spearman rank correlation analysis,0<r<1is related,p<0.05was considered statistically significant. Results:(1) the age ofonset, clinical stage, lymph node metastasis of two groups were different (p<0.05),pathological type was indifferent (p>0.05),(2) five years disease-free survival (DFS) oftwo group was indifferent (p>0.05).(3) the positive expression rate of VEGF and EGFRof the Uygur group was higher than the Han group, the difference between two groups wasstatistically significant (p<0.05), and the Uygur And Han group more than two indicatorsof positive expression with TNM stage and axillary lymph node metastases werepositively related (0<r<1,p<0.05). Conclusion: This paper results indicated the clinicalstage of Uighur group TNBC patients was later, comparing five years with the Hangroup,there was no significant difference in DFS. VEGF and EGFR-positive expressionrate of the Uighur group was higer than Han group, the above results was considered withinstallments late of Uighur group TNBC patients, to study the affect dimension triplenegative breast cancer prognosis factor is needed,and to provide individualized treatmentto provide the basis for further research is needed.