Expression Of Vascular Endothelial Growth Factor In Patients With Triple Negative Breast Cancer In China And Its Relation To Clinicopathologic Features: A Meta-analysis

Objective: To systematically evaluate expression of vascular endothelial growth factor(VEGF)protein in triple negative breast cancer(TNBC)and analyze its correlation between positive expression of VEGF protein and clinicopathologic features of patient with TNBC.Methods: The published literatures relevant VEGF protein expression in TNBC and its relation to clinicopathologic features of patient with TNBC in China were retrieved by means of CNKI,Wanfang,VIP,China Biomedical,Chaoxing Medalink,PubMed databases,and other search tools.The literatures were independently filtered,extracted,and assessed by two reviewers according to the inclusion criteria and exclusion criteria.The meta-analysis was conducted by using RevMan 5.3 software.Results: A total of 11 literatures were included and involved 1 838 patients(750 patients in the TNBC group and 1 088 patients in the non-TNBC group).The results of metanalysis showed that the positive expression of VEGF protein in the TNBC group was significantly higher than that in the non-TNBC group(OR=2.64,95%CI(2.14,3.26),P<0.00001),which was significantly increased in the TNBC patients with positive lymph node or stage III-IV as compared with the negative lymph nodeor stage(P=0.0002)or I-II(P<0.00001).However,the positive expression of VEGF protein was no associated with the age of patients with TNBC or tumor size(P>0.05).Conclusions: VEGF highly expresses in TNBC and it is expected to be a new therapeutic target.Positive expression of VEGF protein is related to positive lymph node and late TNM stage,and it might be associated with prognosis of patient with TNBC.