The Relationship Between The Components Of The Metabolic Syndrome And Early Arterial Function

ObjectiveThe study was to investigate the relationship between metabolic syndrome and early arterial function by analyzing metabolic syndrome and pulse wave velocity (PWV) change, and to study on metabolic syndrome in patients with arterial pulse wave velocity. The study provides a clues to evaluate metabolic syndrome components and the cardiovascular lesions.Aim1. To investigate relationship between metabolic syndrome and early arteriosclerosis.2. To study the association between metabolic syndrome (MS) and the Brachial Ankle pulse Wave Velocity (baPWV).3. To provide basis for early assessment of cardiovascular disease by analyzing of brachial-ankle artery pulse wave velocity and metabolic factors.MethodsA total of5476subjects were enrolled from the annual health checkup subjects. Blood pressure, fasting plasma glucose, waist circumference, triglyceride, cholesterol, high and low-density lipoproteins were measured with standard methods. BaPWV were determined by VP-1000(BP-203RPE Ⅲ).Statistical methods:The result of the value of pulse wave velocity and metabolic components was represented by the median and four percentile interval. Kruskal-Wallis test was used for comparisons of different groups. Correlation and regression were analyed between the components of metabolism and Brachial Ankle pulse wave velocity (baPWV). Significant difference threshold was P≤0.05.Results(1)The median of baPWV in MS Patients were1419.0cm/s and1275.0cm/s in non-MS subjects (P<0.001). The baPWV change rates were16.29%and7.05%espectively in these two groups (P<0.001).(2) Pulse wave velocity were positively correlated to systolic blood pressure, diastolic blood pressure, fasting blood glucose, waist circumference, glycerin three greases, total cholesterol, low density lipoprotein, rs were0.62,0.45,0.22,0.21,0.16,0.15,0.09, respectively (P<0.001).(3)Systolic blood pressure, fasting blood glucose, low-density lipoprotein and triglyceride were the important components which affected the baPWV.ConclusionThe value of pulse wave velocity and abnormal change in patients of metabolic syndrome were higher than those of the non-metabolic syndrome. Ms patients have early alterations on arterial wall elasticity and function. Examination of Pulse wave velocity helps to screen early arteriosclerosis in MS patients.