The Investigation Of Association Between Metabolic Syndrome And Pulse Wave Velocity, And A Preliminary Discussion Of The Intervention Of Metabolic Syndrome

Objective:To analyze the relationship between the change of ankle brachial pulse wave velocity (baPWV) and metabolic syndrome (MetS) as well as other influencing factors in a population based study of Chinese. Method:BaPWV were noninvasively acquired in 1003 subjects who were evaluated by the CDS standard of MetS. Male and female subjects were each categorized into four groups according to baPWV quartiles. Multiple stepwise regression was employed to analyze the independent risk factors of baPWV grading. Male and female subjects were also categorized according to the number of traits of the MetS into one of five groups.Then the difference of baPWV among groups were compared with variance analysis. Result:Multiple stepwise regression revealed age, systolic blood pressure and OGTT2hBG were the independent risk factors for baPWV grading in male subjects. While age, SBP, hypertension history were the independent risk factors for baPWV grading in female subjects. With the increase of the number of MetS traits, the level of baPWV increase significantly in all subjects(P<0.01). Conclusion:Age, SBP, OGTT2hBG, hypertension history were the independent risk factors for baPWV. BaPWV level increased significantly with an increased number of MetS compoments. Objective:To discuss the influence of different intenvetion and patient compliance on the components of Metabolic Syndrome(MetS). Methods:Screening for the Meta-bolic Syndrome in a population who underwent a routine health checkup,28 Mets patients were picked out and randomized to 3 groups (combined therapy group, life style intervention group and control group). After one year intervention metabolic component were observed and compared with before. At the same time, patients were divided into high compliance group and poor compliance group to compare the influence of compliance on the therapy of Mets. Results:Variance analysis indicated the HOMA-IR of combined therapy group and life style group were significantly lower than control group after intervention. However, baPWV and incidence of arteriosclerosis didn't reach statistical significance among 3 groups. High compliance group had decreased BMI after therapy; it also had lower TG and higher HDL compare low compliance group. The compliance of antihypertensive and lipid-lowering agents were lower than antihyperglycemic agents in Mets patients, glycemic control was better than blood pressure, lipid and weight control, but there was no statistical difference. Conclusion:In the early stage of intervention of Mets patients, even when weight loss observed and glycemic control improved, the management of blood pressure and lipid should be strengthened. We should emphasize "blood pressure treat to target" in Mets patients with increased baPWV. Use active combined therapy including anti-hypertensive agents. Short time Combined therapy of Mets patients with long disease history can not significantly change artery stiffness, but insulin resistance can be alleviated. This effect is probably related to weight loss and use of Metformin. The abnormal metabolic components were difficult to be improved in poor compliance patients even they were in combined therapy group.