Joint Detection Of Changes In The Levels Of CRP And FIB And The Impact To COPD

Objective: Preliminary study on the changes of serum C reactive protein (CRP) andfibrinogen (FIB) levels of patients in Acute Exacerbation of Chronic ObstructivePulmonary Disease (AECOPD) and stable phase, to provide a theoretical basis for theearly diagnosis of the AECOPD and the assessment of COPD severity, and evaluationof the therapeutic effectiveness.Method: A case-control study was carried out on37cases of the AECOPD patientsadmitted Respiratory Medicine of our hospital since December2011to July2012.Respectively, At acute stage and remission stage of COPD, sample morning fastingvenous blood for CRP and FIB testing; control group taken on the morning fastingvenous blood of the examination day to detect CRP and FIB. CRP levels weredetected using the USA Beckman specialty protein instrument immage800byturbidimetry, FIB levels were detected using the Japan Sysmex-CA-1500automatedcoagulation analyzer by solidification, both are real-time determination on same day,by professionals strictly according to the instructions. Use SPSS17.0statisticalpackage for statistical analysis. The measurement data were±s, count datacomparison were represented in rate, one-way ANOVA were used to compare amonggroups, q test and t-test was used to compare between groups, P <0.05was consideredstatistically significant; Analyze the correlation between CRP and FIB of the acutephase, the stable phase and the control group using Pearson correlation method, P<0.05(2-tailed) was considered statistically significant.Result:1. CRP, FIB levels of COPD and control groups are not equal, the differencewas statistically significant (P <0.05). In the group of acute exacerbation COPD, CRPand FIB were higher than those in the other two groups (P <0.05); difference betweenFIB and CRP levels of the COPD stable phase and control groups was not statisticallysignificant (P>0.05).2. CRP and FIB levels in patients with acute exacerbation of COPD had a significantpositive correlation at the0.01level (2-tailed), and correlation coefficient r=0.510(P<0.01); CRP and FIB levels in patients with stable COPD had a significant positivecorrelation at the0.05level (2-tailed), the correlation coefficient r=0.349(P <0.05);CRP and FIB levels in control group had no correlation, the correlation coefficient r=0.129(P>0.05).Conclusion:1. The difference between age, smoking, body mass index, gender of COPD groupand control groups has no statistical significance (P>0.05), comparable.2. CRP and FIB were involved in AECOPD inflammatory response; there is a certain value in the diagnosis and treatment of AECOPD.3. In vivo expression of CRP and FIB of COPD may have some relevance; combineddetection of changes in the levels of in vivo CRP and FIB of COPD patients hasprovided a theoretical basis for the early diagnosis of acute exacerbation of COPD,assessment of COPD severity, and evaluation of the therapeutic effectiveness.