Diagnostic Value And Signillcane Of The Anti-Sa Antibodyanti-CCP Antibody, GPI Antigen And Rheumatoid Factor With Rheumatoid Arthritis(RA)

Object：To analyze and detect the diagnostic significane of the anti-Sa antibody，anti-CCP antibody，GPI antigen and rheumatoid factor in patient with RA.Methods：(1) The methods of Enzyme-linked immunosorbent assay(ELISA) was used todetermine the anti-Sa antibody,anti-CCP antibody,GPI antigen and rheumatoid factor in97RA patients、67other autoimmune diseases and49healthy controls from the hospital ofXinjiang Uygur Autonomous Region,RF were deteceted by immunoturbidimetric assay.(2)Collect the clinical data and laboratory index of97RA: age of onset, sex, morning stiffness,the pain number of joints, the swell number of joints, erythrocyte sedimentation rate (ESR),C-reactive protein (CRP), antinuclear antibody (ANA) and calculated the DAS28scores.Results：(1) The specificitiy and sensitivity of anti-Sa antibody，anti-CCP antibody，GPI antigen, RF,RF-IgA,RF-IgG, RF-IgM were95.69%and59.79%,98.28%and90.72%,76.14%and78.35%,67.24%and91.75%,89.66%and58.76%,90.52%and68.04%,79.31%and79.38%.(2) In Patient with RA whose RF is negative,the rate of male ofanti-Sa antibody，anti-CCP antibody，GPI antigen were25.0%、50.0%、50.0%.(3) specificitiyand sensitivity were92.24%-100%and47.42%-86.60%as two index turned out to bepositive;were99.14%-100%and46.39%-71.13%as three index,were100%and46.39%asfour index.(4) The RA patients with anti-Sa were statistically different from the patientswithout this antibody in C-reactive protein.(5) GPI in active RA patients was higher thanstable patients(P<0.05).Conclusion：Dictation of anti-Sa antibody,anti-CCP,GPI and rheumatoid factor cangreatly improve the specificity for diagnosis of early-stage RA.