A Clinical Analysis Of Virus Infection After Allogeneic Peripheral Blood Stem Cell Transplantation

Objective: To investigate incidence, time of occurrence, pathogens distribution, the siteof infection, analysis of possible risk factors and prognosis of virus infection occurredafter allogeneic peripheral blood stem cell transplantation.Methouds:228cases of the patients who undergoing allogeneic peripheral blood stemcell transplantation in Hematology of our hospital from January2004to September2012.The median follow-up time is881d (8d~3215d). Analysis of the incidence of theinfection, the virus type and site of infection,and analysis possible risk factors andprognosis of infection after transplantation.Results:228patients were enrolled,54cases infection occurs, the incidence rate is23.7%.The main type of viruse is varicella-zoster virus, with the incidence rate of13.6%, themedian time is210d (48d~702d); cytomegalovirus infection rate is6.6%, the median timeis54d (35d~1167d), virus infection manifested as skin infections, followed by viremia.Incidence of virus infection is related with ATG of aGVHD occurrence, while unrelatedwith age, gender, ethnicity, primary disease and risk stratification, HLA consistency ofcircumstances, conditioning regimen, source of stem cells, time of neutrophils recovery,occurrence of cGVHD and HC; mortality of virus infection after hematopoietic stem celltransplantation was11.1%, the survivors can reach a cure.Conclusion: Incidence of virus infection after allogeneic peripheral blood stem celltransplantation is not high. zoster virus infection is the most commen, followed bycytomegalovirus infection. Viral infection after transplantation related to ATG and theoccurrence of aGVHD with; prevention of virus infection following allogeneic peripheralblood stem cell transplantation in patients should be strengthen, periodic testing isimportant. Once the active virus infection be found should be actively treated.