| Objective: To determine the effect of short term intensive glycemic control on SAA andCRP in22patients with newly diagnosed type2diabetes mellitus.Research methods: A total of22subjects (14men and8women) with newly diagnosedtype2diabetes, had a course of intensive therapy comprising of3groups. Body mass index,blood pressure, fasting plasma glucose, HbA1c, triglycerides, Cholesterol, HDL-chol, LDL-chol,creatinine, urea, AST, ALT, total bilirubin, CRP,serum amyloid A were measured prior and aftertherapy. The first group was patient on insulin therapy only consisting of7, the second groupconsisted of3patients who were on only oral hypoglycemic agents (OHA) which were onmetformin, acarbose, glimiperide as dual or even triple therapy and finally group3composed of12patients who were on insulin and OHA simultaneously.Results: The intergroup comparison was analysed at baseline and after the intensive therapywas completed and no significant difference was observed for any of the clinical parameters. Thestudy showed that prior and after the intensive therapy fasting plasma glucose, HbA1c, totalcholesterol, HDL and LDL cholesterol were reduced significantly, yielding p=0.00for all theseparameters while SBP and total bilirubin were also significantly decreased.(p=0.005,0.002respectively). Initially lnSAA was only positively correlated to urea level only (r=0.60, p=0.003),while CRP was positively correlated to BMI, SBP, ALT (r=0.63,0.52,0.45and p=0.020,0.013,0.036respectively) and negatively to age, bilirubin.(r=-0.43,-0.57, p=0.047,0.006). Aftertherapy lnSAA was positively correlated to AST only (r=0.51, p=0.015), while CRP showed nocorrelation.Conclusion: The study showed that short term intensive therapy of mean duration of2-3 weeks could decrease these parameters significantly, and no correlation could be establishedbetween fasting plasma glucose or HbA1c and SAA or CRP neither initially at time of diagnosisnor at end of therapy. |
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