The Relativity Between Family History Of Early-onset Of Type2Diabetes Mellitus And Its Complications

Objective: To further investigate the significance of family history in patientswith early-onset type2diabetes mellitus.Methods：This study consisted of430early-onset type2diabetes mellitus cases inthe Department of Endocrinology of the Second Affiliated Hospital of Dalian MedicalUniversity from January2010to November2011. In these cases,267were male and163were female. The cases’ general clinical characteristics, family history of diabetes,anthropometric measurements and biochemical studies were recorded. According to thesituation that whether the case has family history，cases were divided into two groups，a group with family history and the other group without. In addition, the clinicalcharacteristics of the two groups were compared, based on which the family history,complications, and clinical characteristics of the cases with early-onset type2diabetesmellitus were analyzed.Result:1. In patients with early-onset type2diabetes mellitus, the percentage ofthe male is higher than that of the female（62.1%vs.37.9%）. There were284cases withfamily history, which accounted for66%of the total. In the284cases, the male numberwas166which accounted for58.5%, and the female number was118which accountedfor41.5%. In the study, P<0.05, and it was statistically meaningful.2. In patients with positive family history, the number of patients with diabeticmother was116, accounting for40.8%, was higher than that of patients with diabeticfather, accounting for22.5%. After hierarchically processing the family historyaccording to patients’ sex, it was found that in the female patients, the cases withdiabetic mother were obviously more than the cases with diabetic father (66.4%vs.46.9%). Further, the cases with diabetic mother were more than the female cases (66.4%vs.33.6%), P<0.05, and it was statistically meaningful.3. We divided patients into three groups based on their onset age，the group with age between10and20, the other group with age between21and30, and another groupwith age between31and40. In every group of patients, the patients with family historyhad higher proportion than the patients without family history. What is more, the onsetage of patients with family history was smaller than those without (35.58±5.095yearsvs.36.72±4.372years，P<0.05). The findings were statistically significant. Therepatients with family history in the group with age between21and30, accounting for84.4%, more than such cases of the group with age between31and40, accounting for63.9%. P<0.01and the findings were statistically significant.4. We divided patients into three groups based on their onset age. The patientswith diabetic mother from the group with age between21and30had higher proportionthan that of the group with age between31and40(47.4%vs.40.2%), and the patientswith both diabetic parents also had higher proportion (28.9%vs.8.3%, P<0.01). Thefindings were statistically significant.5. According to the level of BMI, all samples were divided into two groups, theoverweight group and the normal group. In the overweight group, the male was morethan the female (61.5%vs.38.5%). P<0.05, and it is statistically significant. LDL-C,TG, HOMA-β, and HOMA-IR of the overweight group were obviously different fromthat of the normal group, it was statistically significant.6. Compared with group without family history of diabetes, the level of HbA1Cand FPG of the group with family history was higher, and the percentage of usinginsulin (68.4%) and antihypertension drugs (68.2%) in the group accounted for higher.P<0.05and it was statistically significant.7. Patients with family history had higher prevalence of diabetic nephropathy andgreater vascular disease than those without (59.7%vs.40.3%P<0.05,63.4%vs.36.6%，P<0.01). The findings were statistically significant.Conclusion:1.The age of onset of patients with family history of early-onset type2diabetes mellitus is much earlier than those without. For the male, their prevalenceratio and positive family history ratio were higher than that of the female. In diabetesinheritance, there was maternal genetic dominance. The offspring of diabetic motherseemed to result in earlier age at diagnosis of type2diabetes mellitus, and the incidenceof male patients was higher than the female patients.2. Early-onset type2diabetes withpositive family history were characterized by more severe glucose metabolic disorder,stronger a personal history of obesity and higher prevalence of fatty liver. Moreover, theproportion of these patients injected with insulin and using antihypertension drugs was higher than those without. Patients with family history had higher prevalence of diabeticnephropathy and vascular disease than those without.3. The overweight patients withfamily history had more severe insulin resistance, lipid and glucose metabolic disorder.4. The susceptible population with family history of diabetes should be paid highattention to. Such population should limit their weight and improve lifestyle, which isvery significant for early-onset type2diabetes prevention.