The Effect Of Family History On The Level Of Inflammatory Factors And Early Stage Secretion Function Of Pancreas Islet

Objective:The dysfunction of p-cell of islet is one of the important links in the development of type 2 diabetes mellitus.In clinical practice,we find that type 2 diabetes melitus has significant family clustering and the age for their offsprings to develop diabetes mellitus is younger than those without family history.The function of pancrease islet exhausts more quickly and in vitro experiment showed that inflammatory factors mediated the damage of p-cell of islet.According to this,it was suspected that inflammatory factors might play an important role in the quicker exhaustion of P-cell of islet in the diabetes patients and their offsprings This study aimed at understanding the effect of family history on the level of inflammatory factors and early stage secretion function of pancreas islet in newly-diagnosed diabetes and non-diabetes through the observation on the change in the level of inflammatory factors and early stage secretion function of pancreas islet in non-diabetes and newly-diagnosed diabetes with(H+) or without(H-) family history and providing theory base for the prevention and cure of diabetes mellitus.Method: We collected 25 newly-diagnosed cases with family history of type 2 diabetes mellitus in Qingdao Han people(TH+group) and 25 cases with normal blood glucose(NH+group).And 25 newly-diagnosed cases without family history(TH-group) and 25 cases with normal blood glucose as the control(NH-group).We used L-arginine simulating test to evaluate the early stage secretion function of pancreas islet,and at the same time detected the level of C-response protein(CRP),interleukin-6 (IL-6) and tumor necrosis factor-α(TNF-α) with ELISA.The insulin resistance index employed homeostasis models(HOMA-IR).Results:1. The change of inflammatory factors and their effect on early stage secretion function of pancreas islet in non-diabetes with family history:(1)Fasting insulin(FINS),INS 2 minutes after arginine stimulation,INS at 4 minute,the first phase net secretion quantity and HOMA-IR in NH+ group are remarkably lower than those in NH- group(P<0.05-0.01);there is no difference between the multiples of the peak to fasting insulin in two groups(P>0.05); (2)CRP and TNF-a in the NH+ group are significantly higher than those in NH- group(P<0.05-0.01) and there is no difference between IL-6 in two groups(P>0.05).2. The change of inflammatory factors in non-diabetes and newly-diagnosed diabetes with family history:TNF-α and CRP in newly-diagnosed diabetes with family history group(TH+) and NH+ group are significantly higher than those in NH- group(P<0.05-0.01); TNF-α,CRP and IL-6 in NH+ group are significantly higher than those in NH- group<0.05-0.01).