The Clinical Research And Safety Evaluation Of Flurbiprofen Axetil Pretreatment On Propofol Injection Pain

Objective:l.To explore the optimal dose and the best time of flurbiprofen axetil pretreatment on propofol injection pain.2.To evaluate the safety of flurbiprofen axetil injection combined with propofol injection.Methods:1.To choose210patients who were induced anesthesia by using propofol injection to induce anesthesia, the American Society of Anesthesiologists (ASA) classification～Ⅱ, age18～70years old. The patients were randomly divided into A, B, C, D, E, F, G seven group,30cases in each group. To compare the incidence and severity of propofol injection pain after5ml saline or0.5,0.75,1mg/kg flurbiprofen axetil intravenous injection+tourniquet venous occlusion for2min; to compare the incidence and severity of propofol injection pain after0.75mg/kg flurbiprofen axetil intravenous injection+tourniquet venous occlusion for0,1,2min or0.75mg/kg flurbiprofen axetil and1.5mg/kg propofol mixture intravenous injection.2.To evaluate safety of flurbiprofen axetil injection, propofol injection and flurbiprofen axetil injection combined with propofol injection by conducting injection site irritation test, active systemic anaphylaxis test, conventional in vitro hemolysis test.Results:1. Compared with saline intravenous injection,0.75,1mg/kg flurbiprofen axetil intravenous injection+tourniquet venous occlusion for2min both obviously decreased the incidence and severity of injection pain, and there was no statistically significant difference between the two groups. The incidences and severities of injection pain of0.75mg/kg flurbiprofen axetil and1.5mg/kg propofol mixture intravenous injection group and0.75mg/kg flurbiprofen axetil intravenous injection +tourniquet venous occlusion for2min group didn’t have significant differences and were better than the0.75mg/kg flurbiprofen axetil intravenous injection+tourniquet venous occlusion for1min group; the incidence and severity of propofol injection pain of propofol immediate injection after0.75mg/kg flurbiprofen axetil intravenous injection was highest.2. There were no hyperemia, bleeding, swelling, necrosis and other abnormal in the injection site in the flurbiprofen axetil injection group, propofol injection group and flurbiprofen axetil injection combined with propofol injection group. The guinea pigs were not symptoms of allergic reactions and no deaths in the flurbiprofen axetil injection group, propofol injection group and flurbiprofen axetil injection combined with propofol injection group. Flurbiprofen axetil injection, propofol injection and flurbiprofen axetil injection combined with propofol injection all didn’t cause rabbit erythrocyte hemolysis or cohesion.Conclusions:1. In the prevention of propofol injection pain,0.75mg/kg flurbiprofen axetil+tourniquet venous occlusion for2min is able to achieve ideal analgesic effect; the effect of0.75mg/kg flurbiprofen axetil and1.5mg/kg propofol mixture intravenous injection is same as0.75mg/kg flurbiprofen axetil intravenous injection+tourniquet venous occlusion for2min, and better than0.75mg/kg flurbiprofen axetil intravenous injection+tourniquet venous occlusion for1min.2. Flurbiprofen axetil injection, propofol injection and flurbiprofen axetil injection combined with propofol injection don’t have apparente irritation, allergic, haemolyticus.