Levetiracetam Monotherapy Children Clinical Observation Of The Epilepsy

Objectives: The study of new antiepileptic drug levetiracetam (LEV, the securityof the trade name Keppra) in the treatment of children the safety, efficacy, retention rate,withdrawal reasons and the influence of EEG.Methods: Select from January2009to January2012in dalian medical universitymedical center2nd affiliated hospital of epilepsy, and choose to take Lev single drugtreatment for epilepsy of50cases, including the27cases, male in23cases, followed up,record its age, gender, EEG and head CT and MRI imaging results, drug related time,the dosage, drug seizures before and after the situation and developing without adversedrug reaction during related material. After every three months a effectivenessevaluation (including has no seizures and epilepsy seizures frequency drop50%ofchildren frequency) and drug safety, and the longest assessment to after24months.Each assessment with Logistic regression model analysis age, sex, epilepsy points type,type, such as the dosage attack may and efficient related factors, synchronous analysisLev monotherapy children the curative effect of epilepsy, adverse reactions, retentionrate and withdrawal reasons.Results: the drug from the start that to the third,6,9,12,15,18,21,24months ofhave no attack rates were41.8%,42.1%,40.6%,39.5%,39.4%,37.7%,38.2%and36.5%, the effective rate was66.9%,64.4%,59.2%,62.3%,61.8%,59.7%,58.5%and50.1%.50cases in oral Lev before the last4weeks of treatment a week on the averagenumber of days without seizures percentage were72%,70%,74%,68%, after treatmentbegan the first four weeks, the number of days a week without seizures percentage were88%,90%,86%,88%. Use Lev treatment for6months after the electroencephalogram,3cases (6%) children epileptiform discharge disappear,21cases (42.0%) of EEGepileptiform discharge reduce more than50%,26cases (52%) improved electroencephalogram is not obvious, without the electroencephalogram increase, easerate48%. After12months of treatment to check again EEG,13cases (26%) childrenepileptiform discharge disappear,29patients (58%) of EEG epileptiform dischargereduce more than50%,8cases (16%) improved electroencephalogram is not obvious,without the electroencephalogram increase, ease rate84%. Nine patients (18%) childrenappeared Lev related adverse reactions, main performance including lethargy, fidgetyirritable, unusual behavior, learning difficulties, sleep disorders, weight gain, etc. Infollow-up period began to3,6,9,12,15,18,21and24months of retention rate were66%,62.4%,58.8%,69.7%,66.3%,60.5%,58.4%and53.2%. Use long-rank inspectionand Cox regression model were risk ratio analysis retention rate and the withdrawal ofthe related factors may, only curative effect, drug use reasons and a way to have astatistical significance. The reasons of stop drug for the treatment of the effect is notideal and prices.Conclusions: Lev can monotherapy new diagnosis of epilepsy children, and to allsorts of attack types of children’s epilepsy are good curative effect. Lev can obviouslyimprove the electroencephalogram. Adverse reaction rare, symptom is light, theduration of the short. The drug retention rate, with good compliance, the mostimportant factor affecting the retention rate is efficacy.