Clinical Observation Of Levofloxacin Combined With Valproic Acid Injection In The Treatment Of Epilepsy

This paper mainly studies therapy efficacy analysis of status epilepticus of the new antiepileptic drugs levetiracetam with valproate,thus to guide the clinical treatment of status epilepticus.Summarized in epilepsy and antiepileptic drugs in treatment of patients, and various kinds of antiepileptic drugs for status epilepticus efficacy were reviewed on the basis of the literature, first of all, from the patients with status epilepticus seizures related parameters to observe effects on the heart, further analysis of epileptic seizure of heart rate, heart rate, myocardial change speculation.Second, from clinical research levetiracetam joint valproate in the treatment of status epilepticus, compared to single drug valproate in the treatment of status epilepticus curative effect, its mechanism, and then discusses the levetiracetam status epilepticus curative effect.Part â… The control study of myocardial injury and after epilepsy seizure in patientsPurpose:Study of epilepsy seizures effect on myocardial, electrocardiogram, heart rate changes.Methods:12lead electrocardiogram (ECG) used to check, before the onset of epilepsy onset and ECG changes after seizures.Ecg monitoring, attack, attack before the onset of patients after heart rate changes, and simultaneous determination, after1h before the onset of epilepsy venous blood myocardial enzymes and myocardial injury markers.And the related data using SPSS17.0statistical analysis, P<0.05is expressed as difference is significant.Results:Epilepsy seizures after1h before the onset of CK comparing CK increased significantly (P<0.01), before the onset of epilepsy seizures after1h CKMB contrast CKMB increased significantly (P<0.01), and epilepsy seizures after1h before the onset of LDH compared LDH increased significantly (P<0.01), and epilepsy seizures after1h cTn I cTn before the onset of contrast I increased significantly (P<0.01).20patients with18cases of heart rate significantly faster during the attack,1case of epilepsy onset heart rate has no obvious change, 1patients heart rate slow down during the attack.Have in12cases with epilepsy seizures ECG abnormal (except sinus tachycardia), and8cases had normal ECG.ST segment of lower in2cases, ST segment elevation in1case, T wave inversion in2cases,2cases of ventricular premature beat, room sex premature beat3cases,1case with long QT, I degree atrioventricular block in1case.Conclusion:Epilepsy seizures are substantially heart rate fluctuations, abnormal electrocardiogram (ecg) and myocardial ischemia change, its mechanism may be related to epilepsy seizures frequently lead to cardiac autonomic nerve disorder caused by. Part â…¡ levetiracetam-valproic acid sodium pump contrast valproic acid sodium pump effect observation of status epilepticusPurpose:Explore levetiracetam oral medication combined with valproate in the treatment of status epilepticus compared to single drug valproate treatment efficacy and safety of status epilepticus.Methods:Valproate group starting to DE ba jin injection1mg/kg.48h, h speed trace continues to pump into a stable condition after DE ba jin oral or BiSi instead. levetiracetam-valproate group starting to valproic acid sodium injection1mg/kg. H trace pump for pumping speed, at the same time inserting nasogastric feeding into every day levetiracetam, the first day of the initial measurement of1g/d, points2times, gradually, until the effective control of seizures, maximum measuring3g/d, in a stable condition, instead of oral drugs.Comparing the effect of the two groups after treatment time, control time, wake up of time, two groups of myocardial enzymes, troponin comparisons.Results:levetiracetam with valproate group therapy in patients with status epilepticus waking time, work time is shorter than the single drug valproate group (P<0.01), levetiracetam in combination with valproate in the treatment of status epilepticus recurrence rate is less than the single drug treatment of status epilepticus (P<0.01), levetiracetam temple in combination with valproate in the treatment of status epilepticus control time effectiveness, control the number of cases, no significant difference (P>0.05), levetiracetam joint valproate group6h after treatment of epilepsy, CK, CKMB, LDH, cTn I significantly lower than the single drug valproic acid sodium group (P<0.01).Conclusion:Oraljoint levetiracetam valproate in the treatment of status epilepticus work fast, good curative effect, the recurrence rate is low, and small damage to the heart, is worth further observation and study.