Correlation Between Serum Lipids Concentration And Coronary Artery Stenosis In Men

Objectives:Investigating the correlation between serum lipids concentration and existence coronary heart disease events as well as severity of coronary atherosclerosis and the severity of coronary heart disease in the men with no diabetes mellitus, in order to help identify the predicting value of serum lipids concentration in these people and provide evidence for the prevention and therapeutics of coronary artery disease.Methods:A retrospective study was conducted on126patients fitting the admission standards from the442ones who underwent their first angiography in the Intervention Center of First Hospital of Shanxi Medical University between January and December in2012. Fasting serum concentrations of TC, TG, HDL-C, LDL-C, LP(a), APOAI, APOB, FBG were measured, and the Age, Blood Pressure and other clinical data were asol collected:the severity of coronary artery stenosis was evaluated by the GS. All patients were classified as control group, single-vessel group, double-vessel group and multiple-vessel group, according to the number of main coronary arteries that have more than50%diameter; All patients were classified as acute myocardial infarction group (AMI), the non-acute myocardial infarction group (NMAI), based on the severity of the disease. The differences between every groups were analyzed by Chi-square test t test analysis of variance. Influencing factors of coronary artery stenosis were analyzed by a multiple linear regression. Influencing factors of coronary heart disease events were analyzed by logistic regression.Results:Between different groups classified by the number of stenotic coronary arteries, the differences of ages LDL-C HDL-C LP (a) werestatistically significant (P<0.05). the differences of TC TG APOB APOAI hypertension were not statistically significant. HDL-C Was significant lower in the multiple-vessel group than in the control group single-vessel group, LDL-C LP (a) was significant higher in the multiple-vessel group than in the control group single-vessel group and double-vessel group, LP (a) was significantly higher in double-vessel group than in the control group, TC APOAI have statistically significant in single-vessel group than in the control group. By multiple linear regression, there were significant relationships between Age LDL-C LP (a) HDL-C and GS in men. The regression equation was: GS=0.229age-0.155HDL-C+0.265LP(a)+0.187LDL-C。 Between cute myocardial infarction group and the non-acute myocardial infarction group, the differences of TC LDL-C HDL-C LP (a) APOB APOAI were not statistically significant. Age LDL-C LP(a)had positive correlation with the coronary heart disease events, HDL-C had negative correlation with the coronary heart disease events, LP (a) HDL-C eventually entered Logestic Regression equation,OR Value were1.004、0.397.Conclusions:There was a negative correlation for HDL-C and positive correlations for TC LDL-C LP(a) age and no significant correlation for TC TG APOB APOAI with the severity of coronary stenosis and coronary heart disease events; The serum lipids concentration can affect the severity of coronary, especially the LP(a).