Association Study Of PARK2and PACRG With Leprosy Susceptibility In Chinese Population

Background: Leprosy is a chronic infectious disease caused by Mycobacterium leprae,affecting both the skin and peripheral nerves. It has long been thought that the host geneticsplay an important role in the development of leprosy. Markers in PARK2and PACRG geneshave been reported to be associated with or linked to susceptibility to leprosy by GWAS,While there is lack of association between polymorphisms of the PARK2and PACRG genesand leprosy susceptibility in more population.Objective: To investigate the association of Single nucleotide polymorphisms of PARK2and PACRG locus with leprosy susceptibility in Chinese population.Methods: A genotyping analysis of the replication study13SNPs located in the region ofPARK2and PACRG was conducted in742leprosy patients and734controls of Chinesepopulation.Results: Eleven previously indicated risk variants and other2SNPs at the PARK2andPACRG locus showed no significant association with leprosy susceptibility in Chinesepopulation.Conclusions: we confirmed that Chinese population, as well as Indian population3, showsno remarkable association with the risk SNPs within the region of PARK2and PACRG withleprosy per se, which imply that these SNPs is associated with the ethnic heterogeneity ofleprosy susceptibility.