The Relationship Between Zoledronic Acid And The Bone Fusion Rate After Cervical Spine Surgery

Objective：To probe whether zoledronic acid (ZOL) infusion5days aftercervical spine surgery affects the risk of nonunion．Methods：From July2009to July2011,146patients of Cervicalspondylosis were treated with surgery, of which data wereanalyzed retrospectively．Each patient received a cervicalX-ray12months postoperatively,then Evaluate of bone fusionrate standard to adjudged if delayed union or nonunion. Filmreview one year after fusion rate assessed according to thestandard [1] namely:(1) Grade Ⅰ: clear fusion, bonetrabecular bridging the gap entirely and re-shaping.(2) GradeⅡ: possible integration of the upper and lower edges of bonetrabecular bone, no fracture, bone margin is not completelyremodeling.(3) Grade Ⅲ: may not be fused bone or the upperedge of the lower edge of the bridge due to the emergence oftrabecular bone is not fractured.(4) Grade Ⅳ: bone absorptionor collapse due to a clear lack of fusion.(5) Grade Ⅴ: cannot be evaluated. Determination of bone delayed union ornonunion ratio. Results：According to the standard, the27patient of ZOL group arecompletely Grade Ⅰ(clearly union).There is no one delayedunion or nonunion. As for the control group, there’s101patients Grade Ⅰ,1patient Grade Ⅱ.Conclusion：ZOL infusion do not affect the bone fusion rate, will not resultin delayed union or nonunion.