Effect Of Periodontal Initial Therapy On Glycometabolism And Lipid Metabolism Of Type2Diabetic Patients With Chronic Periodontitis In Ningxia Hui And Han Populations

Objective The aim of the clinical study was to observe the change of glycometabolismand lipid metabolism of type2diabetic patients with chronic periodontitis in Ningxia Hui andHan populations received periodontal initial therapy,thus to provide clinical references for thetherapeutic schedule and medical decision making of this disease.Methods From June2011to August2012,120type2diabetic patients with chronicperiodontitis including60Hui and60Han were collected from General hospital of Ningxiamedical university.All of them were divided into case group and control group.Each groupwas divided into Hui group and Han group(each group of30cases).All patients were checkedup their periodontal clinical indexes including periodontal probing depth(PD) and attachmentloss(AL).Blood analyses were carried out for glycometabolism including fasting plasma glu-cose(FPG) and glycated hemoglobin(HbA1c) and lipid metabolism including triglyceride(TG)and total cholesterol(TC).The case group received periodontal initial therapy and conventionaldiabetes medication;the control group only received conventional diabetes medication.Allpatients were required for return visit to retest the above indexes at3rdmonths.SPSS11.5statistical software was applied to analyze the results.Results1.Periodontal clinical indexes:PD of the case group was redused obviouslyafter periodontal initial therapy,and the differrences were statistically significant in differentgroups(PPDcase-Hui=0.041,PPDcase-Han=0.043,PPDcase-All=0.006);to a certain extent AL was chang-ed and the differences in different groups were not statistically significant(PALcase-Hui=0.267, PALcase-Han=0.257,PALcase-All=0.109).PD and AL of the control group both were changed barely(PPDcontrol-Hui=0.208,PPDcontrol-Han=0.644,PPDcontrol-All=0.325,PALcontrol-Hui=0.281,PALcontrol-Han=0.791,PALcontrol-All=0.474).The differents of PD and AL between the populations were not stati-stically significant(PPDcase-Hui and Han=0.070,PALcase-Hui and Han=0.512,PPDcontrol-Hui and Han=0.063,PALcontrol-Hui and Han=0.276).There were significant differences of PD between the case groupand the the control group(PPDcase and control-Hui<0.010,PPDcase and control-Han=0.001,PPDcase and control-All<0.010),and the statistical results of AL were opposite to that of PD(PALcase and control-Hui=0.559,PALcase and control-Han=0.218,PALcase and control-All=0.212).2.Biochemical indexes of glycometabolism:There were not significant differences of FPG inthe case group and the the control group(PFPGcase-Hui=0.447,PFPGcase-Han=0.521,PFPGcase-All=0.319,PFPGcontrol-Hui=0.344,PFPGcontrol-Han=0.526,PFPGcontrol-All=0.252).After periodontal initialtherapy,HbA1c of the case at the return visit was lower than the results before(PHbA1ccase-Hui=0.020,PHbA1ccase-Han=0.043,PHbA1ccase-All=0.002);there were no significant differences in HbA1cof the control(PHbA1ccontrol-Hui=0.652,PHbA1ccontrol-Han=0.051,PHbA1ccontrol-All=0.062).The differentsof FPG and HbA1c between the populations were not statistically significant(PFPGcase-Hui and Han=0.779,PHbA1ccase-Hui and Han=0.083,PFPGcontrol-Hui and Han=0.854,PHbA1ccontrol-Hui and Han=0.591).Compared the case with the control,no significant differences were found in FPG(PFPGcase andcontrol-Hui=0.407,PFPGcase and control-Han=0.666,PFPGcase and control-All=0.361);the differences of HbA1cwere statistically significant(PHbA1ccase and control-Han=0.010,PHcA1bcase and control-All=0.009) exceptHui population(PHbA1ccase and control-Hui=0.238).3.Biochemical indexes of lipid metabolism:TG and TC of the case both were lower than theresults before,and there were significant differences(PTGcase-Hui=0.043,PTGcase-Han=0.047,PTGcase-All=0.004,PTCcase-Hui=0.046,PTCcase-Han=0.044,PTCcase-All=0.005).The two indexes of the con-trol did not change significantly after periodontal initial therapy(PTCcontrol-Hui=0.679,PTGcontrol-Han=0.217,PTGcontrol-All=0.254,PTCcontrol-Hui=0.278,PTCcontrol-Han=0.084,PTCcontrol-All=0.846).Thedifferents of TG and TC between the populations were not statistically significant(PTGcase-Hui and Han=0.826,PTCcase-Hui and Han=0.340,PTGcontrol-Hui and Han=0.190,PTCcontrol-Hui and Han=0.097).Nosignificant differences were found between the case and the control in TG and TC(PTGcase andcontrol-Hui=0.727,PTGcase and control-Han=0.073,PTGcase and control-All=0.131,PTCcase and control-Hui=0.112,PTCcase and control-Han=0.278,PTCcase and control-All=0.765).Conclusion1.Periodontal initial therapy can improve the periodontal health and thelevel of HbA1c of type2diabetic patients with chronic periodontitis in Ningxia Hui and Hanpopulations. There are significantly changes in PD.2.Evidence is not enough to supportperiodontal initial therapy can improve lipid metabolism.3.There is no sufficient evident tosupport that periodontal initial therapy maybe acts on Hui and Han populations differently.