The Research On The Concentration Changes Of Serum Lp-PLA₂in Acute Cerebral Infarction And Its Relationship With TTOAST

Objective：To investigate the role of serum Lp-PLA₂in the development ofacute cerebral infarction（ACI），and the relationship between Lp-PLA₂and subtypesby The Trial of Org l0172in Acute Stroke Treatment（TOAST）.Methods： A retrospective case-control study was used,and the data wasprospectively collected from76consecutive ischemic stroke inpatients in ourdepartment from July2012to April2013.The cases of control group were healthypeople at the period time.They were classified into5subtypes shown as follows,1arge-artery atherosclerosis（LAA group）,small-artery occlusion（SAO group）,cardio-embolism（CE group）, stroke of other demonstrated etiology（SOE group）, andstroke of undemonstrated etiology（SUE group）, the concentration changes of serumLp-PLA₂was measured by enzyme-linked immunosorbant assay（ELISA）.And therelationship between Lp-PLA₂level and their TOAST subtypes was analyzed.Results:（1）The serum Lp-PLA₂level of patients were significant higher thanthose of controls,and the difference was statistically significan（tP<0.01）. The level ofserum Lp-PLA₂in LAA group was the highest（P<0.01）.（2）Further logisticregression analysis indicated that Lp-PLA₂had significant correlation withLAA（OR was5.346，95CI%=2.225-12.846，P<0.01）.Conclusion：The serum Lp-PLA₂level varied with different subtypes of ACI，which supported that subtypes varied according to different pathogenies. So it may beone of the markers in patients with ACI.The level of serum Lp-PLA₂in LAA groupwas the highest． Therefore,detection of plasma Lp-PLA₂levels can providetheoretical guidance for the diagnosis of various subtypes of acute ischemic stroke in clinical practice.