The Relationship Between OX-LD LP-PLA2 And Acute Non-cardiogenic Cerebral Infarction

Objective: Cerebral infarction is the second leading cause of death in humans.Atherosclerosis is an important pathophysiological mechanism leading to acute cerebral infarction.In recent years,it has been found that oxidized low-density lipoprotein(OX-LDL)and lipoprotein-associated phospholipase A2(LP-PLA2)can promote the development of atherosclerosis by enhancing oxidative stress.This study was to investigate the relationship between OX-LDL &LP-PLA2 and acute noncardiogenic cerebral infarction.Methods:A total of 120 patients with acute non-cardiogenic cerebral infarction admitted to Department of Neurology,the Second Hospital of Hebei Medical University from December 2016 to December 2017 were selected as the case group,including 79 males and 41 females,with an average age of 62.83 ±11.64 years.All patients were seen within 72 hours of onset and met the inclusion criteria.The case group was grouped according to TOAST classification: 79 cases of large atherosclerosis(LAA)and 41 cases of small artery occlusion(SAO).Thirty healthy volunteers were selected from the health examination centre in the Second Hospital of Hebei Medical University as control group,18 males and 12 females,mean age 58.53 ± 11.53 years.The level of OX-LDL was measured by enzyme-linked immunosorbent assay,and LP-PLA2 level was measured by immunopotentiation turbidimetry.Results:1.The comparison of baseline data between the cerebral infarction group and the control group showed a significant difference in systolic blood pressure,homocysteine,C-reactive protein,and high-density lipoprotein between the two groups(P<0.05).The rest were not statistically different(P<0.05).2.The levels of OX-LDL and LP-PLA2 in the cerebral infarction group were significantly higher than those in the control group,and the differences were statistically significant(P<0.05).Among them,the levels of OX-LDL and LP-PLA2 in the LAA group were significantly higher than those in the SAO group and the control group(P < 0.05).There was no significant difference in the level of OX-LDL between the SAO group and the control group(P<0.05).The level of LP-PLA2 in the SAO group was significantly higher than that in the control group,with a significant difference(P<0.05).3.OX-LDL levels in patients with acute ischemic stroke were significantly and positively correlated with LP-PLA2(R = 0.759,P = 0.000),as well as NIHSS scores at admission(R = 0.267,P = 0.003)(P <0.05).Conclusion:1.The levels of homocysteine,high-sensitivity C-reactive protein,high-density lipoprotein,and systolic blood pressure were significantly increased in patients with acute cerebral infarction.2.There was a significant positive correlation between OX-LDL and LP-PLA2,both of which played an important role in the occurrence and development of cerebral infarction.3.OX-LDL and LP-PLA2 were closely associated with acute noncardiogenic cerebral infarction,with the most significant increase in the LAA group.