Clinical Characteristics Of Patients With Slow Coronary Flow

Objective To analyze the clinical characteristics and pathogenesis of the patientswith slow coronary flow (SCF).Methods By TIMI flow grade method and TIMI frame count method, patientswith chest pain symptom and other symptoms of myocardial ischemia were included.All the patients underwent coronary angiography (CAG) operation in Fujian ProvinceHospital of cardiology from January2011to February2013. Patients with slowcoronary flow and without obvious epicardial coronary arteries stenosis were selectedto SCF group (n=60); Patients with normal coronary flow and without obviousstenosis during the same period the CAG were selected to normal group(n=116);Patients with epicardial coronary artery stenosis and normal blood flow wererandomly selected to coronary heart disease (CHD) group (n=30). Subjects clinicaldatas were recorded, including laboratory indicators like glycometabolism, lipidmetabolism.Results1. Sex ratio (male/female)of the SCF group and normal group was52/8vs66/50respectively(P <0.05). Fasting blood glucose (FBG) abnormalities rate33.3%vs12.1%(P <0.05), dyslipidemia rates40.0%vs22.4%(P <0.05), BMI26.19±3.10vs23.74±3.48(P<0.05) had significantly statistical difference; Sex ratio ofthe SCF group and CHD group was52/8vs26/4respectively(P>0.05). Fastingblood glucose (FBG) abnormalities rate33.3%vs20.0%(P>0.05), dyslipidemiarates40.0%vs36.7%(P>0.05), BMI26.19±3.10vs26.10±2.83(P>0.05)had no statistical difference;2. The multi-factor logistic regression analysis showed that after adjustment ofother factors, gender (OR=5.277,95%CI:1.68810.838, P <0.01), FBGabnormal (OR=2.449,95%CI:1.1315.302, P <0.05), dyslipidemia (OR=2.133,95%CI:1.0564.306, P <0.05) are independent risk factors of SCF;3. The most common vascular involvement of SCF were the three vessels at the same time (n=20), and the most commonly affected vessel was the right coronaryartery (RCA)(n=42);4. There was significantly statistical difference in incidence of hypertension,dyslipidemia positive rate between clinical data and vascular involvement degreeof SCF patients (P <0.05).5. There was significantly statistical difference in TIMI frame count between onevessel, two vessels and three vessels involvement (P <0.001). There wassignificant difference in TIMI frame between one vessel involvement andmultiple vessels involvement (P <0.001).Conclusions1. Our study showed that male patients and patients with dyslipidemia or FBGabnormal could promote and increase the incidence of SCF on the basis oftraditional cardiovascular risk factors, including hypertension, diabetes, smoking;2. The most common vascular involvement of SCF were the three vessels at the sametime, and the most commonly affected blood vessel was the right coronary artery(RCA);3. The more TIMI frame count, the more vascular involvement.