| With the accelerating pace of modern life, the stress of individuals increases. Thecase rate of schizophrenia raises and schizophrenia becomes one of the most commonmental disorders in our nation. The diagnosis for schizophrenia is based on clinicalsymptoms lacking objective biological parameters. There exists obvious abnormalcognitive function besides positive symptoms and negative symptoms in schizophrenicpatients. The recovery of cognitive function is closely related to social function. If thechanges of event-related potentials for the abnormal cognitive function were found, notonly the hypothesis could be certified, but also explainations for various symptoms couldbe provided. The research has practical importance and could provide theory basis for thediagnosis of schizophrenia.The experiment consists two parts: the first part is that38schizophrenia patients ascase group and30healthy subjects as control group took the measure of P300. The P300of the two groups and different illness duration was compared. The second part is that14first-episode schizophrenia cases and30healthy subjects took the measure of P50. The P50of the two groups and changes after therapy were compared.Result:Through the above mentioned research, the outcomes of the first part were as thefollows:1. The reaction time of the case group was significantly longer than that of the controlgroup(t=8.25, P<0.05). The correct ratio between the two groups showed no significantdifference.2. Compared with the control group, the latencies of the case group at C3, C4weresignificantly longer (t=2.56,2.47, P<0.05). The aptitudes at C3,C4, Fz, Cz weresignificantly lower(t=3.12,4.14,4.27,3.08, P<0.05).3. Compared with the first-episode group, the latencies of recurrence group at C3, C4,Fz showed significantly longer(t=2.58,3.07,6.78, P<0.05). The aptitudes at C3,C4, Fz,Cz were significantly lower(t=5.13,4.55,8.35,4.70, P<0.05).The outcomes of the second part are as the follows:1. Compared with the control group, the latency at CZ of S1in first-episode casegroup was longer and aptitude was lower (t=2.27,2.58, P<0.05); the latency and aptitudeof S2showed no significant difference (t=0.49,1.36, P>0.05). The ratio of S2-P50/S1-P50of the first-episode group was significantly higher than that of the control group(t=3.17,P<0.05).2. The Positive and Negative Syndrome Scale(PANSS) was used to evaluate thesymptoms of the first-episode case group. The result showed that the score of PANSS inthe first-episode case group before therapy was significantly higher than that after sixweeks’therapy(t=16.81, P<0.05).3. The latency of S1in the first-episode case group increased to the normal level(t=4.06, P<0.05), and the aptitude showed no significant difference after6weeks’ therapy(t=0.20, P>0.05). The ratio of S2-P50/S1-P50showed no significant difference than thatbefore therapy (t=0.45, P>0.05).Conclusion:Schizophrenic patients have obvious abnormal cognitive function, showing longer aptitudes, lower aptitudes in P300and P50ratio decreased. P300is a state index varyingthe severity of the disease, and P50is a stable index not affected by drug. Event-relatedpotentials can provide theory basis for the diagnosis of schizophrenia. |
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