| The geuns Viburnum, distributed from South America to South-East Asia, is the second large genus of Caprifoliaceae. There are about240species all over the world and about80species in China.43of them are used as folk medicine in China for their biological properties, such as antibacterial, antiinflammatory, antitussive and antinociceptive, being traditionally used for the treatment of menstrual, stomach and kidney cramps. So the Viburnum is a large medical genus. The studies on chemical constituents of this genus have resulted in the isolation of diterpenoids, triterpenoids, iridoids, flavonoids and so on. Many of them have excellent antitumor and antioxidant activities.In this issue, chemical constituents of Viburnum awabuki were studied and14compounds were obtained by the modern chromatogram-phic techniques of chromatography on sillca gel, HPLC, Sephadex LH-20and so on. Their structures were identified as β-amyrin (1), a-amyrin (2), stigmast-4-en-3-one (3), lupeol (4),3β-hydroyolean-12-en-1-one (5), exgosta-4,6,8(14),22-tetraen-3-one (6),28-hydroxyolean-12 -en-3-one (7),(3-amyrone (8), trans-phytol (9), betulin (10),3β-acetoxy-olean-12-en-28-ol(11),3-O-acetyloleanolic acid (12),28-hydroxyl-β-amyrin (13) and28-hydroxyl-a-amyrin (14) by MS, NMR and physico-chemical analysis.The antitumor activitites against to SMMC-7721, Hela and K562of compounds1,2,4,11,12and14were examined by MTT assays. The results showed that the compound1only has activity against Hela and K562cells with IC50values of66.38μg/mL and49.36μg/mL, the other five compounds have activities against to all three tumor cells.This issue also summarized the chemical constituents and biological activities of this genus, and will support the scientific basis to the development and utilization of Viburnum. |
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