Synthesis Of Bendamustine Hydrochloride

Chronic lymphocytic leukemia (CLL) is becaused of apoptosis, blocked lead to B-cell malignant clonal proliferative disease, displays for the mature small lymphocytes in the circumference blood, the marrow, in the liver spleen and other lymphoid tissue’s exceptionally agglomeration, the clinical manifestation is a chronic process, duration up to several months even decades.Bendamustine hydrochloride, product name Treanda, it is used for Chronic lymphocytic leukemia (CLL). It is a bifunctional alkylating agent. Its mechanism is by alkylation of DNA single and double strand cross-linking, interfering with DNA function and DNA synthesis, which exert antitumor effects.Based on the2,4-Dinitrochlorobenzene as the starting material, by substitution, reduction, acylation, cyclization, reduction, substitution, hydrolization, salification and other steps, successful synthesis of the target product of bendamustine hydrochloride. The target product by NMR testing, characterization of the structure.This paper makes some optimization of the reaction process and reaction conditions, scale-up production the products obtained the customer’s identity. This route has the synthesis raw material easy to get, stable chemical property, mild reaction condition, high yield, and is suitable for industrialized production.