Studies On Inorganic-Organic Hybrid Fluorescent Chemosensors Based On BODIPY Derivatives

Fluorescent probes which have the advantages of high sensitivity, good selectivity, and easy to operate are widely used in the detection of a variety of cations, anions and neutral molecules. Therefore, many people concern the design and synthesis of more efficient fluorescent molecules. This article focuses on BODIPY fluorescent dyes which have high efficiency of molar extinction coefficient, high efficiency of absorbance, good light stability, high fluorescence quantum yield and good sensitivity. BODIPY is a widely studied chromophore. Di-(2-picolyl)amine is a good chelator of several metal ions. It can chelate different metal ions in different conditions. So, in this paper, we described some nano fluorescent chemosensors based on difluoroboron dipyrromethene and Di-(2-picolyl) as fluorophore and detector respectively. This paper is divided into three chapters.The first chapter mainly focuses on the background of the research, basic knowledge and recognition mechanism of fluorescent probes, the development of the probes of Cu2+、Cd2+and Zn2+, and the progress of BODIPY dyes.In the second chapter, we designed and synthesized a highly responsive nano fluorescent chemosensor of Cd2+and Zn2+. It has been prepared by a nucleophilic substitution of the fluorescent dye3-chloro-4,4-difluoro-8-(4-tolyl)-5-[bis(pyridin-2-ylmethyl)amino]-4-bora-3a,4a-diaza-s-indacene with aminated nano hydroxyapatite. The HA particles were prepared with3-(aminopropyl)triehtoxysilane (THA-APTES). In the EtOH/H2O (95/5V/V) solution, the nano fluorescent probe can form1:1complexes with Cd2+or Zn2+ion, producing an instant color change along with a large hypsochromic shift in the absorption and fluorescence spectra by approximately70nm and35nm respectively and a large cation-induced fluorescence amplification.In the third chapter, we designed and synthesized a highly responsive nano fluorescent chemosensor of Cu2+. It has been prepared by a nucleophilic substitution of the fluorescent dye3-chloro-4,4-difluoro-8-(4-tolyl)-5-[bis(pyridin-2-ylmethyl)amino]-4-bora-3a,4a-diaza-s-indacene with aminated silica nanoparticles (SN). The SN particles were prepared with 3-(aminopropyl)triehtoxysilane (THA-APTES). In the EtOH/H2O (1/1V/V) solution, the nano fluorescent probe can form1:1complexes with Cu2+ions, producing an instant color change along with a large hypsochromic shift in the absorption spectra by approximately70nm.