Design, Preparation And Perfermance Study Of Controlled Release Systems Based On Mesoporous Silica Nanoparticles(MSNs) And One Sensor For Lithium Ions

Mesoporous silica materials have some attractive features, such as large surface areas and pore volumes, highly ordered mesoporous structures and perfect biocompatibility, therefore they have an increasingly wide range of applications for controlled ralease of drugs, the adsorption and separation of metal ions. Here, we designed and synthesized two kinds of controlled release systems based on mesoporous silica nanoparticles (MSNs). Their structures were characterized by FT-IR, SEM, TEM, DLS, XRD and BET. The results showed that the as-synthesized MSNs had typical mesoporous structures. In addition, we designed and synthesized one sensor for lithium ions.1. Based on the competitive binding between 4--Aminoantipyrene, Luminol and Horseradish Peroxidase (HRP), MSNs N 5 was designed and synthesized. The release profiles demonstrated that N 5 had a high load capacity and behaved "zero premature release". Luminol can competitively combinate with the HRP in N 5 to open the pore, which resulted in the effective release of loaded dyes. The release rate and amount of dyes increased with the increase of concentration of sbustrate Luminol, which showed that N 5 had perfect controlled release properties.2. We functionalized the MSNs with 2-amino-2-deoxy-D-glucose (Inhibitor) inside of the mesopores and the external surface of the particles. By the specific combination of Glucose Oxidase and Inhibitor, we obtained the MSNs P 6 with a perfect capability of controlled release. The release profiles demonstrated that P 6 had a high load capacity and showed no early release. The mesopores can be opened by glucose, which can competitively combinate with the Glucose Oxidase in P 6 and resulted in the effective release of loaded dyes. P 6 had a perfect selectivity for glucose over other monosaccharides, and can be further developed for real-time detection of glucose in vivo.3. Based on tetramethyl-14-crown-4 (TM14C4, Acceptor) and 1,8-naphthalimide (Fluorophore), we designed and synthesized one sensor FS1 for Li+. All the obtained compounds were characterized by 1H NMR,13C NMR and HRMS. The UV absorption and fluorescence of FS1 did not change significantly after the addition of the lithium ions, but the Mass Spectrometry showed that FS1 can combine with Li+.