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Application Of Functional Magnetic Resonance Imaging (fmri) Adversary Needle Therapy For Stroke Hemiplegia Afterbrain Function Restore Mechanism Research

Posted on:2014-01-19Degree:DoctorType:Dissertation
Country:ChinaCandidate:Z Y ShenFull Text:PDF
GTID:1224330398452840Subject:Chinese medical science
Abstract/Summary:PDF Full Text Request
This subject use complex brain network, study of scalp acupuncture treatment of stroke hemiplegia with fMRI, so can explore acupuncture-specific affecting brain activation functional areas, can be proved efficacy mechanism of the traditional chinese medicine therapy’s Scalp acupuncture and overall regulation effect of the hub. Also, study of residual brain tissue remodeling and functional compensatory pathway accurately prove mechanism of recovering motorfunction after stroke hemiplegia. Using of modern medical theory, Information Processing Technology and the theory of tradit ional Chinese medicine, Mul t idiscipl inary concept. In this study, a preliminary exploration Chinese medicine acupuncture own peculiarity, also can take generally recognized innovative research and evaluat ion methods of this research’s area. Using complex brain network technology, analyze the effects of scalp acupuncture on the image data.The study intervenes the participants with scalp acupuncture and applies fMRI.Objective:Using brain network, part of the two groups, gather resting-state data, analysis connectioning node of motor functioning area and time correlation between the various functional areas. Also using causal model approach, analysis interaction between the brain regions of motor function, thereby, reveal possible mechanisms that reorganization of patients with hemiplegia’s motor funct ion and brain remodel ing. Compara t i ve analysis for two groups of data. The study with scalp acupuncture complex brain network technology and the role of scalp acupuncture on brain functional networks sites. Further study the complex brain network in a pilot study of acupuncture methodological issues.Methods:Using a random number table, the patients were divided into two groups, scalp acupuncture group and the control group. Before using scalp acupuncture and after two weeks, respectively collect fMRI imaging data and evaluation of clinical neurological scale. Two groups of patients were included before using scalp acupuncture and after two weeks of the MRI, collect twice data of structures like resting functions like.Results:We analys is motor funct ion network of pat ients with hemiplegia. Observe clinical indicators, compare this network of control group and scalp acupuncture group, probe acupuncture on the brain networks and brain motor function damage repair remodeling mechanism. Because our observation object is motor function damage, therefore core of study for motion function network is data analysis, based on a priori knowledge of the anatomical structure and literature, in the resting state data processing, wedecide M1functional areas as ROT, according to the time sequence analysis of functional connectivity, obtain results brain regions of motor functionwith associated M1, there are temporal correlation between brain regions. Therefore, we believe that functional connectivity among brain regions, is an important part of the motor function network. By compared Result between before and after acupuncture treatment, compare with acupuncture group and non-acupuncture group, we found that this motor function have a dynamic change, changed Features is Changes in degree of strength about connection of brain area.Conclusion:According to the results, suggest members of brain regions constituted motor function network in patients with hemiplegia is important functional areas of bra in:M1, SMA, Cerebel lum, brainstem, precuneus, Lingual gyrus, cingulate gyrus, inferior parietal lobule, insula, caudate nucleus. At present coord inat ion mediani sm among the network is not clea r, there will be recovery of process and arise brain regions’s dynamic fluctuations in the network with acupuncture treatment. A comparison of pre-and post-Scalp acupuncture group results are presented, in the right anterior cingulate, right medial frontal gyrus, left parietal precuneus, right caudate nucleus body emergence phenomenon of functional connectivity enhancements. This is acupuncture’s effects lead to be enhanced brain function connection.
Keywords/Search Tags:Brain plasticity, fMRI, Hemiplegia, Scalp acupuncture, Stroke
PDF Full Text Request
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