| Purpose：To observe the impact of bone health capsule rabbit model of kneeosteoarthritis of the knee joint synovial IL-1.Material and method：33rabbits were randomly divided into treatment groups of10, the modelgroup11and a control group of12. Administration group, model group lineHulth technique replicated the model of osteoarthritis after5w600mg/kggavage administration of group health Capsule, model group and control groupgiven normal saline orally administered three weeks after anatomicalmicroscope downstream cartilage Pelletier, JP, score, take the medialfemoral condyle articular cartilage line Masson and toluidine blue stainingobserved collagen fibers in cartilage proteoglycan content changes,immunohistochemical detection of cartilage and synovium of IL-1expressionsituation.Results：Bone health capsules can delay the loss of articular cartilage matrixin osteoarthritis, the cartilage and synovial IL-1expression of thetreatment group was significantly lower than the model group (P <0.05). |
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