Access Relieving Soup Flavored To Ulcerative Colitis Model Rats Colon Tissue Adhesion Factor Expression

Purpose：Through the jia wei tong fu soup to ulcerative colitis in the rat modelof adhesion molecules colon organization model influence and mechanismresearch,from ulcerative colitis in the rat model to gobble up the cell membraneglycoprotein CD44, soluble adhesion molecules P choose meat CD62p between cells,soluble adhesion molecules-1CD54three aspects, explore Chinese medicinecolitis and soup to ulcerative colitis the treatment effect of the rat model,adhesive molecular expression differences and the significance of thedifferences, in order to traditional Chinese medicine to ulcerative colitis toprovide the basis.Material and method：This study rats for experimental animals,using the relatively advancedSan Xiao Ji Ben sulfonic acid (TNBS)-ethanol ulcerative colitis animal model,application randomized controlled grouping scheme. After the drug with flowcytometry detector observed each rat colon tissue adhesion molecules (devourcell membrane glycoprotein CD44, soluble adhesion molecules P choose meat CD62pbetween cells, soluble adhesion molecules-1CD54) expression differenceschanges. Through the analysis of variance to find out of jia wei tong fu soupulcerative colitis in the rat model colon tissue factor influence of adhesionexpress,know the curative effect and the formula of the medicine in the ratmodel ulcerative colitis colon organization the change of adhesion factor,understand ulcerative colon disease and before and after treatment after theadhesion of factor expression,to determine jia wei tong fu soup to ulcerativecolitis in the rat model have definite therapy effect.Results：Through the analysis of variance analysis the data of the experiments, the rat colon tissue adhesion molecules (devour cell membrane glycoprotein CD44,soluble adhesion molecules P choose meat CD62p between cells, soluble adhesionmolecules-1CD54) expression of normal levels than model group low, a statisticalsignificance, adhesion factor expression and ulcerative colitis diseases;Thetreatment group of normal group compared with model, jia wei tong fu soup dosegroup of senior high school, western medicine data set and normal group nostatistical significance, says the drugs have therapeutic effect, low dose groupof colitis and party, repair bowel pill group and spleen normal group havestatistical significance, explain efficacy not exact; Colitis and low dosecompared three groups party, high school than low is statistically significant,high school dose curative effect of better;Colitis and high school dose andliu nitrogen party sulfonylurea pyridine is no statistically significant, andjia wei tong fu soup in low doses, fill spleen bowel pill group compared arestatistically significant, explain colitis and curative effect is equivalentto the western medicine control group party curative effect, traditional Chinesemedicine is better than the control group curative effect.Conclusion：1colitis and in high doses of the group and the party dose equivalent to westernmedicine curative effect of nitrogen liu sulfonylurea pyridine group, higherthan fill spleen and low dose group of intestinal pill. jia wei tong fu souphave clear proof curative effect.2the normal group rat colon tissue adhesion molecules (devour cell membraneglycoprotein CD44, soluble adhesion molecules P choose meat CD62p between cells,soluble adhesion molecules-1CD54) expression is low, the model group increasedcompared that adhesion factor and the onset of jia wei tong fu soup a mutualrelationship, can guide the healing index.3colitis and low dose compared three groups of party, the curative effect ofhigh school measurement is good, clinical can choose measurement in treatmentgroup with ulcerative colitis.