Meridian Shu Capsule Treatment Of Diabetic Peripheral Neuropathy Clinical Observation

Objective:To observe the clinical efficacy of JingLuoShu capsule treatment on diabetic peripheral neuropathy(DPN), objective evaluation of the effectiveness、security、and the advantages of Chinese medicine on the treatment of diabetic peripheral neuropathy, and explore its possible mechanism of action for the clinical use of the drug treatment of DPN to provide a reference and to determine research directions.Method:40DPN patients met the diagnostic criteria and the criteria for inclusion were randomly divided into the treatment group and the control group. based on the basic treatment, treating respectively by JingLuoShu capsule and macobalamin, six weeks for one treatment. The changes of symptoms, signs intergrals, the main laboratory test, electromyo graphy, nerve conductive velocity were compared after treatment between two groups, all data were stated and analysed by t-test, χ2-test and Ridit analysis.Results:TCM syndromes to principal syndrome total effective rate of treatment group was85%,65%in the control group, two groups have a certain effect of symptom improvement, but the treatment group was higher than that in the control group, comparing the two groups, there was significant difference (P<0.05); neurosigns total effective rate of treatment group was85%, which was superior to that of control group65%, two groups compared to the significant differences (P<0.05);in EMG treatment group and control group, to compare MCV、SCV、 Lat with the treatment, there are significant or very significant difference (respectively P<0.01and P<0.05). between groups treatment compared to treatment group was significantly better than the control group, with significant differences (P<0.05) or very significant difference (P <0.01). Conclusion:The treatment group was obviously superior to the control group of TCM syndrome、 electromyography test indicators. Patients was well tolerated and no adverse reactions. Its mechanism may be the JingLuoShu capsule with activating blood circulation to dissipate blood stasis, anti-inflammatory analgesic, and expansion of peripheral vascular effects, can treat or mitigate diabetes Diabetes, peripheral nerve injury and other symptoms. This Prescription have low prices and good effect, easy to take orally, which fully demonstrates the advantages and characteristics of Chinese medicine treatment of DPN, This Prescription can further research and development into a new drugs.