Golden Aged Rats With Kidney Pills And Movement Of The Research On The Effects Of Bone Mineral Density And Bone Metabolism

1. ObjectiveExplore the influence of bone mineral density and the bone metabolism on Jinkui shenqi wanand movement for elderly female rats, so as to look scientific and reasonable intervention metho-ds and theoretical basis for preventing osteoporosis.2. Methods12months female,80wistar rats and6weeks female10wistar rats were selected,80wistarrats by weight randomly are divided into eight groups. That is the control group, medication grou-p,20min exercise group,40min exercise group,60min exercise group, medication+20minexercise group, medication+40min exercise group and medication+60min exercise group. Inthe adapt to feed, after a week the experiment starts. To adapt to a training run2days about the six exercise group, starting8weeks of stomach and filling machine movement run, rats were fasted for12hours, and then taken the blood by picking the eyeball and the carved femur to Measureealcium（Ca）， alkalin PhosPhatase in bones （AKP） and bone mineral density （BMD）, which areall dataused SPSS17.0software for statistieal analysis.3.results3.1each group of big mouse blood serum Ca²⁺contentThe blood serum Ca²⁺content, compared with the control group which taking medicine,20min and the60min movement takes medicine the group, the40min movement group obviouslyreduces the （P<0.05）,40min movement to take medicine the group to be remarkably reduced（P<0.01）,and is also obviously lower than the group which taking medicine purely and the40minmovement group （P<0.05）.3.2each group of big mouse blood serum STR-ACP activenessThe blood serum STR-ACP activeness, compared with the control group which taking medi-cine,20min and the60min movement takes medicine the group, the40min movement group ob-viously reduces the （P<0.05）,40min movement to take medicine the group to be remarkably red-uced （P<0.01）,it is also obviously lower than the group which taking medicine purely and the40min movement group （P<0.05）.3.3each group of big mouse bone tissue ALP activenessThe bone tissue ALP activeness, compared with the control group, other groups extremelyobviously elevate（P<0.001）; the group With taking medicine purely and the40min movement gr-oup compares, the40min movement taking medicine group is extremely remarkable elevated（P<0.01）With20min, the60min movement group compares, the40min movement group obviou-sly elevates （P<0.05）.3.4each group of big mouse bone density The big mouse bone density, compared with the control group, other groups obviously elev-ates （P<0.001）; With the taking medicine purely group and the40min movement group compar-es, the40min movement that takes medicine group is extremely elevated （P<0.01）； With20mi-n, the60min movement group compares, the40min movement group are obviously elevated（P<0.05）.4. Conclusions4.1middle and old age female big mouse passes through8week-long different physiological loa-d of exercise trainings. it discovered the oxygen movement to reduce the STR-ACP activenessand increase the deposition of bone calcium, it can inhibit the bone absorption.4.2after rats taking the medicine8weeks, we can find that it has a significant role in reducing t-he activity of STR-ACP in serum and Ca²⁺content, increase the deposition of the bone calciumand increase ALP activity and BMD obviously.So the pill can inhibit absorption of the bone andincrease the deposition of the bone calcium, it can promote the bone restoration.4.3Jinkuishenqiwan combined with aerobic exercise to inhibit bone absorption, promote boneformation and increase bone density better than the simple movement and simple medicationeffect, indicating that taking Jinkui shenqi wan and appropriate exercise intervention to treatmentof senile osteoporosis loose there is a certain.